Synonym
Diphenidol pamoate; SKF478-J; SKF-478-J; SKF 478-J
IUPAC/Chemical Name
2-Naphthalenecarboxylic acid, 4,4-methylenebis(3-hydroxy-, compd. with alpha,alpha-diphenyl-1-piperidinebutanol
InChi Key
WVPDEFZZHNQFFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H16O6.C21H27NO/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-2,4-7,11-14,23H,3,8-10,15-18H2
SMILES Code
O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.OC(C5=CC=CC=C5)(C6=CC=CC=C6)CCCN7CCCCC7
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
697.83
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Leung YM, Wong KL, Cheng KS, Kuo CS, Su TH, Chen YW, Cheng TH. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44. doi: 10.1016/s1734-1140(12)70869-1. PMID: 22814027.
7: Lin HT, Chiu CC, Wang JJ, Hung CH, Chen YW. High frequency transcutaneous electrical nerve stimulation with diphenidol administration results in an additive antiallodynic effect in rats following chronic constriction injury. Neurosci Lett. 2015 Mar 4;589:62-6. doi: 10.1016/j.neulet.2015.01.026. Epub 2015 Jan 14. PMID: 25596445.
8: Yang L, Shen M, Xiang P, Shen B, Deng H, Qiang H, Dang Y, Shi Y. Application of a Validated UPLC-MS-MS Method for the Determination of Diphenidol in Biological Samples in 15 Authentic Lethal Cases. J Anal Toxicol. 2020 Oct 13:bkaa160. doi: 10.1093/jat/bkaa160. Epub ahead of print. PMID: 33048121.
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