IUPAC/Chemical Name
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
InChi Key
JIVRLHBAUUZTNC-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14N2O5/c1-25-17-9-12(8-11-4-2-3-5-14(11)17)19-16-7-6-13(20(23)24)10-15(16)18(21)22/h2-10,19H,1H3,(H,21,22)
SMILES Code
O=C(O)C1=CC([N+]([O-])=O)=CC=C1NC2=CC(OC)=C3C=CC=CC3=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
338.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dwivedi R, Drumm BT, Alkawadri T, Martin SL, Sergeant GP, Hollywood MA,
Thornbury KD. The TMEM16A blockers benzbromarone and MONNA cause intracellular
Ca2+-release in mouse bronchial smooth muscle cells. Eur J Pharmacol.
2023 May 15;947:175677. doi: 10.1016/j.ejphar.2023.175677. Epub 2023 Mar 24.
PMID: 36967079.
2: Oh SJ, Hwang SJ, Jung J, Yu K, Kim J, Choi JY, Hartzell HC, Roh EJ, Lee CJ.
MONNA, a potent and selective blocker for transmembrane protein with unknown
function 16/anoctamin-1. Mol Pharmacol. 2013 Nov;84(5):726-35. doi:
10.1124/mol.113.087502. Epub 2013 Aug 30. PMID: 23997117; PMCID: PMC3807079.
3: Boedtkjer DM, Kim S, Jensen AB, Matchkov VM, Andersson KE. New selective
inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh)
-A01 and MONNA - what do they inhibit? Br J Pharmacol. 2015 Aug;172(16):4158-72.
doi: 10.1111/bph.13201. Epub 2015 Jul 8. PMID: 26013995; PMCID: PMC4543620.
