MedKoo Cat#: 413791 | Name: Dioxamycin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dioxamycin is new benz[a]anthraquinone antibiotic isolated from strain MH406-SF1, closely related to Streptomyces xantholiticus.

Chemical Structure

Dioxamycin
Dioxamycin
CAS#134861-62-4

Theoretical Analysis

MedKoo Cat#: 413791

Name: Dioxamycin

CAS#: 134861-62-4

Chemical Formula: C38H40O15

Exact Mass: 736.2367

Molecular Weight: 736.72

Elemental Analysis: C, 61.95; H, 5.47; O, 32.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dioxamycin
IUPAC/Chemical Name
(2S,4S,5S)-2,4-dimethyl-5-((1E,3E,5E)-7-(((2R,6R)-2-methyl-6-((2R,3S,4aR,12bS)-2,3,4a,8,12b-pentahydroxy-3-methyl-1,7,12-trioxo-1,2,3,4,4a,7,12,12b-octahydrotetraphen-9-yl)tetrahydro-2H-pyran-3-yl)oxy)-7-oxohepta-1,3,5-trien-1-yl)-1,3-dioxolane-2-carboxylic acid
InChi Key
HWMMBHOXHRVLCU-QOUANJGESA-N
InChi Code
InChI=1S/C38H40O15/c1-18-23(51-26(39)10-8-6-5-7-9-24-19(2)52-36(4,53-24)34(45)46)13-14-25(50-18)20-11-12-21-27(29(20)40)30(41)22-15-16-37(48)17-35(3,47)32(43)33(44)38(37,49)28(22)31(21)42/h5-12,15-16,18-19,23-25,32,40,43,47-49H,13-14,17H2,1-4H3,(H,45,46)/b6-5+,9-7+,10-8+/t18-,19+,23?,24+,25-,32+,35+,36+,37+,38-/m1/s1
SMILES Code
C[C@@H]1O[C@@](O[C@H]1/C=C/C=C/C=C/C(OC2CC[C@H](c3c(O)c4c(C(C5=C(C4=O)C=C[C@@]6(C[C@](O)([C@H](C([C@]56O)=O)O)C)O)=O)cc3)O[C@@H]2C)=O)(C(O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 736.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sawa R, Matsuda N, Uchida T, Ikeda T, Sawa T, Naganawa H, Hamada M, Takeuchi T. Dioxamycin, a new benz[a]anthraquinone antibiotic. J Antibiot (Tokyo). 1991 Apr;44(4):396-402. doi: 10.7164/antibiotics.44.396. PMID: 2032948. 2: Kim BY, Zucchi TD, Fiedler HP, Goodfellow M. Streptomyces cocklensis sp. nov., a dioxamycin-producing actinomycete. Int J Syst Evol Microbiol. 2012 Feb;62(Pt 2):279-283. doi: 10.1099/ijs.0.029983-0. Epub 2011 Mar 11. PMID: 21398501. 3: Igarashi M, Watanabe T, Hashida T, Umekita M, Hatano M, Yanagida Y, Kino H, Kimura T, Kinoshita N, Inoue K, Sawa R, Nishimura Y, Utsumi R, Nomoto A. Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10. J Antibiot (Tokyo). 2013 Aug;66(8):459-64. doi: 10.1038/ja.2013.33. Epub 2013 May 1. PMID: 23632918.