MedKoo Cat#: 561425 | Name: BNC-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BNC-1 is a novel modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and activation of Elk-1.

Chemical Structure

BNC-1
CAS#96335-59-0

Theoretical Analysis

MedKoo Cat#: 561425

Name: BNC-1

CAS#: 96335-59-0

Chemical Formula: C16H14N2O3

Exact Mass: 282.1004

Molecular Weight: 282.30

Elemental Analysis: C, 68.08; H, 5.00; N, 9.92; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BNC-1; BNC 1; BNC1;
IUPAC/Chemical Name
Methyl 2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-1-carboxylate
InChi Key
GKRYSUZXCCOHLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14N2O3/c1-8-12-14(13(9(2)17-8)16(20)21-3)10-6-4-5-7-11(10)18-15(12)19/h4-7H,1-3H3,(H,18,19)
SMILES Code
O=C(C(C(C)=NC(C)=C12)=C2C3=CC=CC=C3NC1=O)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lovell MA, Lynn BC, Fister S, Bradley-Whitman M, Murphy MP, Beckett TL, Norris CM. A Novel Small Molecule Modulator of Amyloid Pathology. J Alzheimers Dis. 2016 May 4;53(1):273-87. doi: 10.3233/JAD-151160. PubMed PMID: 27163808. 2: Hermanstyne TO, Markowitz K, Fan L, Gold MS. Mechanotransducers in rat pulpal afferents. J Dent Res. 2008 Sep;87(9):834-8. PubMed PMID: 18719209; PubMed Central PMCID: PMC2577312. 3: Wang J, Zhang S, Schultz RM, Tseng H. Search for basonuclin target genes. Biochem Biophys Res Commun. 2006 Oct 6;348(4):1261-71. Epub 2006 Aug 10. PubMed PMID: 16919236; PubMed Central PMCID: PMC1630671. 4: DeSimone JA, Lyall V, Heck GL, Feldman GM. Acid detection by taste receptor cells. Respir Physiol. 2001 Dec;129(1-2):231-45. Review. PubMed PMID: 11738657.