MedKoo Cat#: 413747 | Name: Diphenhydramine salicylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diphenhydramine salicylate is a combination of a sleep aid and a pain reliever. It is used to treat patients with minor backaches that have trouble sleeping.

Chemical Structure

Diphenhydramine salicylate
Diphenhydramine salicylate
CAS#7491-10-3 (salicylate)

Theoretical Analysis

MedKoo Cat#: 413747

Name: Diphenhydramine salicylate

CAS#: 7491-10-3 (salicylate)

Chemical Formula: C24H27NO4

Exact Mass: 0.0000

Molecular Weight: 393.48

Elemental Analysis: C, 73.26; H, 6.92; N, 3.56; O, 16.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Synonym
Diphenhydramine salicylate; Ibelomin; Salibena; Zeresmin
IUPAC/Chemical Name
Benzoic acid, 2-hydroxy-, compd with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
InChi Key
RTSZUSOHOIFYSY-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H21NO.C7H6O3/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;8-6-4-2-1-3-5(6)7(9)10/h3-12,17H,13-14H2,1-2H3;1-4,8H,(H,9,10)
SMILES Code
O=C(O)C1=CC=CC=C1O.CN(C)CCOC(C2=CC=CC=C2)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 393.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hoffman LM. Migraine. J Fam Pract. 1993 Sep;37(3):225-6. PMID: 8105020. 2: POMERANITZ N, HYMAN JB, LAI MS, WALLACH R. HEMORRHAGIC DIATHESIS DUE TO SALICYLATE-INDUCED HYPOPROTHROMBINEMIA. N Y State J Med. 1964 Mar 15;64:795-9. PMID: 14130796. 3: Kamijo Y, Soma K, Sato C, Kurihara K. Fatal diphenhydramine poisoning with increased vascular permeability including late pulmonary congestion refractory to percutaneous cardiovascular support. Clin Toxicol (Phila). 2008 Nov;46(9):864-8. doi: 10.1080/15563650802116151. PMID: 18608279. 4: Sharma AN, Hexdall AH, Chang EK, Nelson LS, Hoffman RS. Diphenhydramine- induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003 May;21(3):212-5. doi: 10.1016/s0735-6757(02)42248-6. PMID: 12811715. 5: Kato H, Yoshimoto K, Ikegaya H. Two cases of oral aspirin overdose. J Forensic Leg Med. 2010 Jul;17(5):280-2. doi: 10.1016/j.jflm.2010.03.001. Epub 2010 Apr 14. PMID: 20569957. 6: Marshall LL. Angioedema associated with aspirin and rofecoxib. Ann Pharmacother. 2005 May;39(5):944-8. doi: 10.1345/aph.1E546. Epub 2005 Apr 5. PMID: 15811906. 7: Weinman D, Nicastro O, Akala O, Friedman BW. Parenteral treatment of episodic tension-type headache: a systematic review. Headache. 2014 Feb;54(2):260-8. doi: 10.1111/head.12287. Epub 2014 Jan 16. PMID: 24433525. 8: Wang C, Han W, Tang X, Zhang H. Evaluation of drug release profile from patches based on styrene-isoprene-styrene block copolymer: the effect of block structure and plasticizer. AAPS PharmSciTech. 2012 Jun;13(2):556-67. doi: 10.1208/s12249-012-9778-3. Epub 2012 Apr 3. PMID: 22476973; PMCID: PMC3364401. 9: Gu H, Hu B, Li J, Yang S, Han J, Chen H. Rapid analysis of aerosol drugs using nano extractive electrospray ionization tandem mass spectrometry. Analyst. 2010 Jun;135(6):1259-67. doi: 10.1039/b923991j. Epub 2010 Mar 10. PMID: 20498877. 10: Shenai N, Shulman J, Gopalan P, Cheng E, Cerimele JM. Fetal Outcomes in Intentional Over-the-Counter Medication Overdoses in Pregnancy. Psychosomatics. 2018 Jul-Aug;59(4):400-404. doi: 10.1016/j.psym.2017.11.007. Epub 2017 Nov 24. PMID: 29277425.