Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms.
MedKoo Cat#: 329859
Name: Diphenhydramine HCl
CAS#: 147-24-0 (HCl)
Chemical Formula: C17H22ClNO
Exact Mass: 0.0000
Molecular Weight: 291.82
Elemental Analysis: C, 69.97; H, 7.60; Cl, 12.15; N, 4.80; O, 5.48
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 10.0 | 34.27 | ||
| DMSO | 59.3 | 203.32 | ||
| Ethanol | 39.1 | 133.85 | ||
| PBS (pH 7.2) | 10.0 | 34.27 | ||
| Water | 79.0 | 270.72 |
The following data is based on the product molecular weight 291.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
