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MedKoo Cat#: 413736 | Name: Albuterol Free Base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Albuterol Free Base is a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.

Chemical Structure

Albuterol Free Base
Albuterol Free Base
CAS#18559-94-9 (free base)

Theoretical Analysis

MedKoo Cat#: 413736

Name: Albuterol Free Base

CAS#: 18559-94-9 (free base)

Chemical Formula: C13H21NO3

Exact Mass: 239.1521

Molecular Weight: 239.32

Elemental Analysis: C, 65.25; H, 8.85; N, 5.85; O, 20.06

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 350.00 2 Weeks
5g USD 650.00 2 Weeks
10g USD 950.00 2 Weeks
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Related CAS #
18559-94-9 (free base) 50293-91-9 (S-HCl) 149234-09-3 (stearate) 51293-66-4 (HCl) 149234-08-2 (adipate) 51022-70-9 (sulfate)
Synonym
Albuterol Free Base; HSDB7206; HSDB-7206; HSDB 7206; Salbutamol; Proventil; Ventoline; AH 3365; AH3365; AH-3365; (±)-Salbutamol; DL-Salbutamol
IUPAC/Chemical Name
4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol
InChi Key
NDAUXUAQIAJITI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
SMILES Code
CC(C)(NCC(c1cc(CO)c(O)cc1)O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Libretto SE. A review of the toxicology of salbutamol (albuterol). Arch Toxicol. 1994;68(4):213-6. doi: 10.1007/s002040050059. PMID: 8067892. 2: Large-volume, preservative-free albuterol concentrate. Med Lett Drugs Ther. 2020 Nov 2;62(1610):173-174. PMID: 33429403. 3: Page CP, Morley J. Contrasting properties of albuterol stereoisomers. J Allergy Clin Immunol. 1999 Aug;104(2 Pt 2):S31-41. doi: 10.1016/s0091-6749(99)70271-x. PMID: 10452786. 4: Ameredes BT, Calhoun WJ. Levalbuterol versus albuterol. Curr Allergy Asthma Rep. 2009 Sep;9(5):401-9. doi: 10.1007/s11882-009-0058-6. PMID: 19671384. 5: Asmus MJ, Hendeles L. Levalbuterol nebulizer solution: is it worth five times the cost of albuterol? Pharmacotherapy. 2000 Feb;20(2):123-9. doi: 10.1592/phco.20.3.123.34776. PMID: 10678290. 6: Quinn C. The cost effectiveness of levalbuterol versus racemic albuterol. Am J Manag Care. 2004 Jul;10(5 Suppl):S153-7. PMID: 15354680. 7: Chen L, Chen X, Zhi C, Li X, Hu Y. Levalbuterol vs. albuterol for hospitalized patients with COPD in China: cost-utility and budget impact analysis. J Med Econ. 2022 Jan-Dec;25(1):966-973. doi: 10.1080/13696998.2022.2096892. PMID: 35786135. 8: Sottas CE, Anderson BJ, Holford NH. Salbutamol has rapid onset pharmacodynamics as a bronchodilator. Acta Anaesthesiol Scand. 2016 Oct;60(9):1328-31. doi: 10.1111/aas.12769. Epub 2016 Jul 21. PMID: 27439596. 9: Ostovar H, Jones J, Brown M. Best evidence topic report. Nebulised levalbuterol or albuterol for lowering serum potassium. Emerg Med J. 2005 May;22(5):366-7. doi: 10.1136/emj.2005.024414. PMID: 15843710; PMCID: PMC1726786. 10: Ameredes BT, Calhoun WJ. (R)-albuterol for asthma: pro [a.k.a. (S)-albuterol for asthma: con]. Am J Respir Crit Care Med. 2006 Nov 1;174(9):965-9; discussion 972-4. doi: 10.1164/rccm.2606001. PMID: 17060667. 11: Puig A, McElligott S, Bergquist H, Doshi JA. Albuterol and levalbuterol use and spending in Medicare beneficiaries with chronic obstructive pulmonary disease. Am J Geriatr Pharmacother. 2010 Dec;8(6):571-82. doi: 10.1016/S1543-5946(10)80006-6. PMID: 21356506. 12: Ahrens R, Weinberger M. Levalbuterol and racemic albuterol: are there therapeutic differences? J Allergy Clin Immunol. 2001 Nov;108(5):681-4. doi: 10.1067/mai.2001.119407. PMID: 11692088. 13: Weinberger M, Hendeles L. Levalbuterol. Ann Allergy Asthma Immunol. 2003 Dec;91(6):587-8; author reply 588-9. doi: 10.1016/S1081-1206(10)61541-4. PMID: 14700446. 14: Gupta SK, Das S. Salbutamol. J Indian Med Assoc. 1973 Nov 1;61(9):388-92. PMID: 4599204. 15: Salbutamol. Aust Nurses J. 1981 Nov;11(5):32-4, 38. PMID: 6916597. 16: Kirkland SW, Vandenberghe C, Voaklander B, Nikel T, Campbell S, Rowe BH. Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma. Cochrane Database Syst Rev. 2017 Jan 11;1(1):CD001284. doi: 10.1002/14651858.CD001284.pub2. PMID: 28076656; PMCID: PMC6465060. 17: Ménégol-Couque B, Brard M. Salbutamol [Salbutamol]. Soins Gynecol Obstet Pueric Pediatr. 1985 Nov;(54):I-II. French. PMID: 3853925. 18: Slattery D, Wong SW, Colin AA. Levalbuterol hydrochloride. Pediatr Pulmonol. 2002 Feb;33(2):151-7. doi: 10.1002/ppul.10027. PMID: 11802253. 19: Dachs R, Darby-Stewart A, Graber MA. Albuterol vs. levalbuterol for asthma treatment in children. Am Fam Physician. 2008 May 1;77(9):1214-6. PMID: 18540484. 20: Handley DA. Single-isomer beta-agonists. Pharmacotherapy. 2001 Mar;21(3 Pt 2):21S-27S. doi: 10.1592/phco.21.4.21s.34261. PMID: 11253864.