HRE-664 | CAS# 105275-74-9 | Antibiotic

MedKoo Cat#: 576378 | Name: HRE-664

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HRE-664 is a synthetic penem antibiotic.

Chemical Structure

HRE-664

CAS#105275-74-9

Theoretical Analysis

MedKoo Cat#: 576378

Name: HRE-664

CAS#: 105275-74-9

Chemical Formula: C15H14N2O6S

Exact Mass: 350.0573

Molecular Weight: 350.34

Elemental Analysis: C, 51.43; H, 4.03; N, 8.00; O, 27.40; S, 9.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HRE-664; HRE 664; HRE664

IUPAC/Chemical Name

4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(4-(aminocarbonyl)phenoxy)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-

InChi Key

MVTIDDWEBUVRRW-XIDCRBKBSA-N

InChi Code

InChI=1S/C15H14N2O6S/c1-6(18)9-12(20)17-10(14(21)22)15(24-13(9)17)23-8-4-2-7(3-5-8)11(16)19/h2-6,9,13,18H,1H3,(H2,16,19)(H,21,22)/t6-,9+,13-/m1/s1

SMILES Code

C[C@@H](O)[C@@H]1[C@H]2SC(=C(N2C1=O)C(=O)O)Oc3ccc(cc3)C(=O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 350.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Fuchs PC, Barry AL, Jones RN, Aldridge KE. An in vitro evaluation of HRE 664, a novel penem antibiotic. Diagn Microbiol Infect Dis. 1988 Sep;11(1):29-40. doi: 10.1016/0732-8893(88)90071-5. PMID: 3219818. 2. Chin XN, Neu HC. In vitro activity of HRE 664, a penem antibiotic. Diagn Microbiol Infect Dis. 1990 Nov-Dec;13(6):509-16. doi: 10.1016/0732-8893(90)90083-8. PMID: 2279381. 3. Aldridge KE, Jones RN, Barry AL, Gelfand MS. In vitro activity of various antimicrobial agents against Staphylococcus aureus isolates including fluoroquinolone- and oxacillin-resistant strains. Diagn Microbiol Infect Dis. 1992 Aug;15(6):517-21. doi: 10.1016/0732-8893(92)90101-x. PMID: 1330418.