VK-II-36 is a Carvedilol analogue inhibits triggered activities evoked by both early and delayed after depolarizations. VK-II-36 inhibits ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity. The RyR2 may be a potential target for treating focal ventricular arrhythmias triggered by either EADs or DADs.
MedKoo Cat#: 555941
Name: VK-II-36
CAS#: 955371-66-1
Chemical Formula: C26H26N2O5
Exact Mass: 446.1842
Molecular Weight: 446.50
Elemental Analysis: C, 69.94; H, 5.87; N, 6.27; O, 17.92
The following data is based on the product molecular weight 446.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
