LY3509754 is an orally bioavailable small-molecule inhibitor of interleukin-17A (IL-17A), developed to block IL-17A-mediated pro-inflammatory signaling implicated in autoimmune diseases like psoriasis. In preclinical models, LY3509754 demonstrated potent inhibition of IL-17A-induced cytokine production with an IC₅₀ in the low nanomolar range (reported ~2–10 nM in cell-based assays).
MedKoo Cat#: 126486
Name: LY3509754
CAS#: 2452464-73-0
Chemical Formula: C24H27F5N8O4
Exact Mass: 586.2075
Molecular Weight: 586.52
Elemental Analysis: C, 49.15; H, 4.64; F, 16.20; N, 19.11; O, 10.91
The following data is based on the product molecular weight 586.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
