MedKoo Cat#: 125994 | Name: UNC5293
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UNC5293 is a MERTK -selective and potent inhibitor ( Ki=190 pM).

Chemical Structure

UNC5293
UNC5293
CAS#2226789-82-6

Theoretical Analysis

MedKoo Cat#: 125994

Name: UNC5293

CAS#: 2226789-82-6

Chemical Formula: C30H42N6O2

Exact Mass: 518.3369

Molecular Weight: 518.71

Elemental Analysis: C, 69.47; H, 8.16; N, 16.20; O, 6.17

Price and Availability

Size Price Availability Quantity
5mg USD 500.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 2,050.00 2 Weeks
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Related CAS #
No Data
Synonym
UNC5293; UNC 5293; UNC-5293
IUPAC/Chemical Name
(2,6-dimethylpyridin-4-yl)(4-(7-(4-hydroxycyclohexyl)-2-(pentan-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)piperidin-1-yl)methanone
InChi Key
MSWOWUREQODTRO-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34)
SMILES Code
CCCC(C)NC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4CCN(CC4)C(=O)C5=CC(=NC(=C5)C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 518.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zheng H, Zhao J, Li B, Zhang W, Stashko MA, Minson KA, Huey MG, Zhou Y, Earp HS, Kireev D, Graham DK, DeRyckere D, Frye SV, Wang X. UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem. 2021 Aug 5;220:113534. doi: 10.1016/j.ejmech.2021.113534. Epub 2021 May 17. PMID: 34038857.