Synonym
Dimethylhemin; Hemin dimethyl ester
IUPAC/Chemical Name
iron(III) 13,17-bis(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-3,8-divinylporphyrin-21,22-diide chloride
InChi Key
LBWRWFGAIQYAIL-RVODVDAYSA-M
InChi Code
InChI=1S/C36H36N4O4.ClH.Fe/c1-9-23-19(3)27-15-28-21(5)25(11-13-35(41)43-7)33(39-28)18-34-26(12-14-36(42)44-8)22(6)30(40-34)17-32-24(10-2)20(4)29(38-32)16-31(23)37-27;;/h9-10,15-18H,1-2,11-14H2,3-8H3;1H;/q-2;;+3/p-1/b27-15-,28-15-,29-16-,30-17-,31-16-,32-17-,33-18-,34-18-;;
SMILES Code
[Cl-].[Fe+3].COC(=O)CCC1=C(C)c2cc3nc(cc4[n-]c(cc5nc(cc1[n-]2)c(CCC(=O)OC)c5C)c(C)c4C=C)c(C)c3C=C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
680.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu Y, Xiong E, Li X, Li J, Zhang X, Chen J. Sensitive electrochemical assay of alkaline phosphatase activity based on TdT-mediated hemin/G-quadruplex DNAzyme nanowires for signal amplification. Biosens Bioelectron. 2017 Jan 15;87:970-975. doi: 10.1016/j.bios.2016.09.069. PubMed PMID: 27668724.
2: Fader CM, Salassa BN, Grosso RA, Vergara AN, Colombo MI. Hemin induces mitophagy in a leukemic erythroblast cell line. Biol Cell. 2016 Apr;108(4):77-95. doi: 10.1111/boc.201500058. PubMed PMID: 26773440.
3: Xue S, Jing P, Xu W. Hemin on graphene nanosheets functionalized with flower-like MnO2 and hollow AuPd for the electrochemical sensing lead ion based on the specific DNAzyme. Biosens Bioelectron. 2016 Dec 15;86:958-65. doi: 10.1016/j.bios.2016.07.111. PubMed PMID: 27498321.
4: Liu F, Tang J, Xu J, Shu Y, Xu Q, Wang H, Hu X. Low potential detection of indole-3-acetic acid based on the peroxidase-like activity of hemin/reduced graphene oxide nanocomposite. Biosens Bioelectron. 2016 Dec 15;86:871-8. doi: 10.1016/j.bios.2016.07.089. PubMed PMID: 27494811.
5: Tripathi AK, Singh N. Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis: Implications for Cerebral Hemorrhage and Sporadic Creutzfeldt-Jakob Disease. J Alzheimers Dis. 2016;51(1):107-21. doi: 10.3233/JAD-151039. PubMed PMID: 26836195.
