Vadocaine | CAS#72005-58-4

MedKoo Cat#: 341367 | Name: Vadocaine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vadocaine is a biochemical.

Chemical Structure

Vadocaine

CAS#72005-58-4

Theoretical Analysis

MedKoo Cat#: 341367

Name: Vadocaine

CAS#: 72005-58-4

Chemical Formula: C18H28N2O2

Exact Mass: 304.2151

Molecular Weight: 304.43

Elemental Analysis: C, 71.02; H, 9.27; N, 9.20; O, 10.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Vadocaine; Vadocainum; Vadocaina.

IUPAC/Chemical Name

(+-)-6'-Methoxy-2-methyl-1-piperidinepropiono-2',4'-xylidide

InChi Key

UJCARUGFZOJPMI-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H28N2O2/c1-13-11-14(2)18(16(12-13)22-4)19-17(21)8-10-20-9-6-5-7-15(20)3/h11-12,15H,5-10H2,1-4H3,(H,19,21)

SMILES Code

Cc1cc(c(c(c1)OC)NC(=O)CCN2CCCCC2C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 304.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Karttunen P, Silvasti M, Virta P, Saano V, Nuutinen J. The effects of vadocaine, dextromethorphan, diphenhydramine and hydroxyzine on the ciliary beat frequency in rats in vitro. Pharmacol Toxicol. 1990 Aug;67(2):159-61. PubMed PMID: 2255670. 2: Silvasti M, Karttunen P, Tukiainen H, Mykkänen M, Ottoila P. Steady state pharmacokinetics of the new antitussive compound vadocaine hydrochloride. Arzneimittelforschung. 1990 Apr;40(4):453-6. PubMed PMID: 2357246. 3: Silvasti M, Karttunen P, Tukiainen H, Mykkänen M, Hänninen U, Välttilä S. The single dose and steady-state pharmacokinetics of a vadocaine tablet in healthy human volunteers. Int J Clin Pharmacol Ther Toxicol. 1989 Nov;27(11):558-63. PubMed PMID: 2613390. 4: Karttunen P, Uusitupa M, Helin M, Tukiainen H, Silvasti M. Assessment of the safety margin of vadocaine hydrochloride in man. Arzneimittelforschung. 1988 Apr;38(4A):642-6. PubMed PMID: 3395404. 5: Karttunen P. Assessment of the antitussive effect of vadocaine hydrochloride using citric acid-induced cough in healthy volunteers. Arzneimittelforschung. 1988 Apr;38(4A):639-41. PubMed PMID: 3395403. 6: Karttunen P, Männistö PT, Tukiainen H, Uusitupa M, Nissinen E. Pharmacokinetics of graded single doses of the novel antitussive compound vadocaine hydrochloride in healthy male volunteers. Arzneimittelforschung. 1988 Apr;38(4A):635-8. PubMed PMID: 3395402. 7: Karttunen P, Tukiainen H, Uusitupa M, Männistö PT. First human studies on the safety and antitussive activity of vadocaine hydrochloride. Arzneimittelforschung. 1988 Apr;38(4A):631-4. PubMed PMID: 3395401. 8: Vuorela A, Mäntylä R, Männistö PT. Tissue distribution of the novel antitussive compound vadocaine hydrochloride in white female mice studied by whole-body autoradiography. Arzneimittelforschung. 1988 Apr;38(4A):628-30. PubMed PMID: 3395400. 9: Mäntylä R, Männistö PT, Vuorela A, Nissinen E. Preliminary pharmacokinetics of the new antitussive compound vadocaine hydrochloride in animals. Arzneimittelforschung. 1988 Apr;38(4A):624-7. PubMed PMID: 3395399. 10: Etemadzadeh E, Ahtee L, Männistö PT. Comparative studies on the dependence liability of morphine hydrochloride, codeine phosphate and two novel antitussive compounds vadocaine hydrochloride and N-(2',4'-dimethyl-6'-methoxyphenyl)-4-(diethylamine) butanamide hydrochloride in mice. Arzneimittelforschung. 1988 Apr;38(4A):620-3. PubMed PMID: 3395398. 11: Paakkari I, Svartström-Fraser M. Cardiovascular and ventilator effects of vadocaine hydrochloride in urethane-anaesthetized rats and guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):617-9. PubMed PMID: 3395397. 12: Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):609-12. PubMed PMID: 3395396. 13: Karttunen P, Männistö PT, Lahovaara S, Havas A. Studies on the nonspecific central nervous system effects of the novel antitussive compound vadocaine hydrochloride. Arzneimittelforschung. 1988 Apr;38(4A):605-8. PubMed PMID: 3395395. 14: Männistö PT, Karttunen P, Lahovaara S, Nissinen E, Davies JE, Algate DR, Baines MW. Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models. Arzneimittelforschung. 1988 Apr;38(4A):598-604. PubMed PMID: 3395394. 15: Vadocaine hydrochloride. A novel antitussive compound. Arzneimittelforschung. 1988 Apr;38(4A):597-646. PubMed PMID: 3395393. 16: Kangasaho M. Effects of lidocaine, codeine and vadocaine hydrochloride on platelet aggregation in human platelet-rich plasma. Arzneimittelforschung. 1988 Apr;38(4A):613-6. PubMed PMID: 2840087. 17: Hanhijärvi H, Voipio HM, Huuskonen H, Männistö P, Nevalainen T. Experimental compound OR-K-242-HCl an anilide derivative slows conduction velocity of the heart in the conscious beagle dog. Arch Toxicol Suppl. 1986;9:213-6. PubMed PMID: 3468900.