Synonym
Dexoxadrol Free Base; HSDB7675; HSDB-7675; HSDB 7675
IUPAC/Chemical Name
d-(+)-2,2-Diphenyl-4-(2'-piperidyl)-1,3-dioxolane
InChi Key
HGKAMARNFGKMLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2
SMILES Code
C1(C2NCCCC2)OC(C3=CC=CC=C3)(C4=CC=CC=C4)OC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
309.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sax M, Wünsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem. 2006;6(7):723-32. doi: 10.2174/156802606776894483. PMID: 16719812.
2: Aepkers M, Wünsch B. Structure-affinity relationship studies of non- competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. Bioorg Med Chem. 2005 Dec 15;13(24):6836-49. doi: 10.1016/j.bmc.2005.07.030. Epub 2005 Sep 19. PMID: 16169732.
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6: Thurkauf A, Mattson MV, Richardson S, Mirsadeghi S, Ornstein PL, Harrison EA Jr, Rice KC, Jacobson AE, Monn JA. Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure- activity relationships. J Med Chem. 1992 Apr 17;35(8):1323-9. doi: 10.1021/jm00086a001. PMID: 1349351.
7: Pilapil C, Contreras P, O'Donohue TL, Quirion R. Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain. Neurosci Lett. 1985 May 1;56(1):1-6. doi: 10.1016/0304-3940(85)90431-8. PMID: 4011043.
8: Williams MW, Williford EA Jr, Williams CS, Towne JC. Clinical analgesic activity of dexoxadrol. Arch Int Pharmacodyn Ther. 1969 Mar;178(1):26-30. PMID: 4187619.
9: Brown LW, Forist AA. Kinetics of acid-catalyzed hydrolysis of dexoxadrol. J Pharm Sci. 1973 Aug;62(8):1365-7. doi: 10.1002/jps.2600620835. PMID: 4725191.
10: Moerschbaecher JM, Brocklehurst C, Devia C, Faust WB. Effects of kappa agonists and dexoxadrol on the acquisition of conditional discriminations in monkeys. J Pharmacol Exp Ther. 1987 Nov;243(2):737-44. PMID: 2824758.
