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MedKoo Cat#: 597993 | Name: Peptide 78

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase.

Chemical Structure

Peptide 78
Peptide 78
CAS#132116-62-2

Theoretical Analysis

MedKoo Cat#: 597993

Name: Peptide 78

CAS#: 132116-62-2

Chemical Formula: C60H106N22O20S

Exact Mass: 1486.7674

Molecular Weight: 1487.70

Elemental Analysis: C, 48.44; H, 7.18; N, 20.71; O, 21.51; S, 2.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Peptide 78; Peptide-78; Peptide78; Thr-met-arg-lys-pro-arg-ser-gly-asn-pro-asp-val-ala-asn;
IUPAC/Chemical Name
(S)-3-((S)-1-(L-threonyl-L-methionyl-L-arginyl-L-lysyl-L-arginyl-L-serylglycyl-L-asparaginyl)pyrrolidine-2-carboxamido)-4-(((S)-1-(((S)-1-(((S)-3-amino-1-carboxy-3-oxopropyl)(propyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
InChi Key
OPKCDFWAZKOPFX-OMBAYSRHSA-N
InChi Code
InChI=1S/C60H106N22O20S/c1-7-21-81(40(58(101)102)26-42(63)86)56(99)30(4)72-55(98)46(29(2)3)80-52(95)36(25-44(88)89)78-53(96)39-16-12-22-82(39)57(100)37(24-41(62)85)73-43(87)27-71-47(90)38(28-83)79-50(93)34(15-11-20-70-60(67)68)75-48(91)32(13-8-9-18-61)74-49(92)33(14-10-19-69-59(65)66)76-51(94)35(17-23-103-6)77-54(97)45(64)31(5)84/h29-40,45-46,83-84H,7-28,61,64H2,1-6H3,(H2,62,85)(H2,63,86)(H,71,90)(H,72,98)(H,73,87)(H,74,92)(H,75,91)(H,76,94)(H,77,97)(H,78,96)(H,79,93)(H,80,95)(H,88,89)(H,101,102)(H4,65,66,69)(H4,67,68,70)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1
SMILES Code
O=C(N)C[C@@H](C(O)=O)N(CCC)C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H]1N(C([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,487.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang T, Wang S, Zheng Q, Wang L, Li Q, Wei M, Du Z, Fan Y. Increased plasma levels of epithelial neutrophil-activating peptide 78/CXCL5 during the remission of Neuromyelitis optica. BMC Neurol. 2016 Jul 11;16:96. doi: 10.1186/s12883-016-0622-3. PubMed PMID: 27401736; PubMed Central PMCID: PMC4940958. 2: Wang H, Zhao J, Xue G, Wang J, Wu J, Wang D, Dong L. Regulatory effect of cytokine-induced neutrophil chemoattractant, epithelial neutrophil-activating peptide 78 and pyrrolidine dithiocarbamate on pulmonary neutrophil aggregation mediated by nuclear factor-κB in lipopolysaccharide-induced acute respiratory distress syndrome mice. Exp Ther Med. 2016 Sep;12(3):1785-1794. Epub 2016 Jul 13. PubMed PMID: 27602092; PubMed Central PMCID: PMC4998193. 3: Zats GM, Kovaliov M, Albeck A, Shatzmiller S. Antimicrobial benzodiazepine-based short cationic peptidomimetics. J Pept Sci. 2015 Jun;21(6):512-9. doi: 10.1002/psc.2771. Epub 2015 Mar 25. PubMed PMID: 25807936. 4: Buer BC, Chugh J, Al-Hashimi HM, Marsh EN. Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. Biochemistry. 2010 Jul 13;49(27):5760-5. doi: 10.1021/bi100605e. PubMed PMID: 20527804. 5: Melchiori A, Albini A, Ray JM, Stetler-Stevenson WG. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6. PubMed PMID: 1313744. 6: Lim JB, Chung HW. Serum ENA78/CXCL5, SDF-1/CXCL12, and their combinations as potential biomarkers for prediction of the presence and distant metastasis of primary gastric cancer. Cytokine. 2015 May;73(1):16-22. doi: 10.1016/j.cyto.2015.01.010. Epub 2015 Feb 14. PubMed PMID: 25689618. 7: Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014 May 29;588(11):2016-24. doi: 10.1016/j.febslet.2014.04.030. Epub 2014 May 4. PubMed PMID: 24801175. 8: Li Z, Wang Z, Zhang C, Chen J, Su Y, Huang J, Yi Z, Yuan C, Hong W, Wang Y, Wu Z, Hu Y, Cao L, Peng D, Guan Y, Zou Y, Yu S, Cui D, Fang Y. Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study. Psychoneuroendocrinology. 2017 Jul;81:113-121. doi: 10.1016/j.psyneuen.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28441588.