MedKoo Cat#: 555931 | Name: E4CPG
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

E4CPG, also known as (RS)-ECPG), is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist.

Chemical Structure

E4CPG
E4CPG
CAS#170846-89-6

Theoretical Analysis

MedKoo Cat#: 555931

Name: E4CPG

CAS#: 170846-89-6

Chemical Formula: C11H13NO4

Exact Mass: 223.0845

Molecular Weight: 223.23

Elemental Analysis: C, 59.19; H, 5.87; N, 6.27; O, 28.67

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,650.00 2 Weeks
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Synonym
E4CPG; (RS)-ECPG; (RS)ECPG; (RS) ECPG
IUPAC/Chemical Name
4-(1-amino-1-carboxypropyl)benzoic acid
InChi Key
AIEFWRHRHFRLFT-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H13NO4/c1-2-11(12,10(15)16)8-5-3-7(4-6-8)9(13)14/h3-6H,2,12H2,1H3,(H,13,14)(H,15,16)
SMILES Code
O=C(O)C1=CC=C(C(C(O)=O)(N)CC)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 223.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shpak G, Zylbertal A, Yarom Y, Wagner S. Calcium-activated sustained firing responses distinguish accessory from main olfactory bulb mitral cells. J Neurosci. 2012 May 2;32(18):6251-62. doi: 10.1523/JNEUROSCI.4397-11.2012. PMID: 22553031; PMCID: PMC6622135. 2: Lu J, Goula D, Sousa N, Almeida OF. Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors. Neuroscience. 2003;121(1):123-31. doi: 10.1016/s0306-4522(03)00421-4. PMID: 12946705. 3: Zhao L, Levine ES. BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol. 2014 Mar;111(5):1008-15. doi: 10.1152/jn.00554.2013. Epub 2013 Dec 11. PMID: 24335212; PMCID: PMC3949235. 4: Bedingfield JS, Kemp MC, Jane DE, Tse HW, Roberts PJ, Watkins JC. Structure- activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol. 1995 Dec;116(8):3323-9. doi: 10.1111/j.1476-5381.1995.tb15142.x. PMID: 8719814; PMCID: PMC1909163. 5: Beirith A, Santos AR, Calixto JB. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res. 2002 Jan 11;924(2):219-28. doi: 10.1016/s0006-8993(01)03240-1. PMID: 11750907. 6: Patenaude C, Chapman CA, Bertrand S, Congar P, Lacaille JC. GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol. 2003 Nov 15;553(Pt 1):155-67. doi: 10.1113/jphysiol.2003.049015. Epub 2003 Sep 8. PMID: 12963794; PMCID: PMC2343476.