U0124 | CAS# 108923-79-1 | U0126 Analog

MedKoo Cat#: 574931 | Name: U0124

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

U0124 is an inactive analog of U0126, a known MEK inhibitor. It does not inhibit MEK activity and has no effect on c-Fos and c-Jun protein or mRNA levels. Due to its inactivity, U0124 is commonly used as a negative control in studies investigating MEK inhibition.

Chemical Structure

U0124

CAS#108923-79-1

Theoretical Analysis

MedKoo Cat#: 574931

Name: U0124

CAS#: 108923-79-1

Chemical Formula: C8H10N4S2

Exact Mass: 226.0347

Molecular Weight: 226.32

Elemental Analysis: C, 42.46; H, 4.45; N, 24.76; S, 28.33

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550.00	2 Weeks

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Related CAS #

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Synonym

U0124

IUPAC/Chemical Name

Bis[amino(methylthio)methylene]butanedinitrile

InChi Key

LBQNBMSPTURKGS-KQQUZDAGSA-N

InChi Code

InChI=1S/C8H10N4S2/c1-13-7(11)5(3-9)6(4-10)8(12)14-2/h11-12H2,1-2H3/b7-5+,8-6+

SMILES Code

N#CC(/C(C#N)=C(N)/SC)=C(N)\SC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 226.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. Immunology. 2008 Feb;123(2):171-80. doi: 10.1111/j.1365-2567.2007.02684.x. Epub 2007 Jul 28. PMID: 17662043; PMCID: PMC2433295. 14: Li S, Samaj J, Franklin-Tong VE. A mitogen-activated protein kinase signals to programmed cell death induced by self-incompatibility in Papaver pollen. Plant Physiol. 2007 Sep;145(1):236-45. doi: 10.1104/pp.107.101741. Epub 2007 Jul 27. PMID: 17660353; PMCID: PMC1976568. 15: Hurtado C, De Robertis EM. Neural induction in the absence of organizer in salamanders is mediated by MAPK. Dev Biol. 2007 Jul 15;307(2):282-9. doi: 10.1016/j.ydbio.2007.04.049. Epub 2007 May 6. PMID: 17540356; PMCID: PMC2096472. 16: Koide N, Ito H, Mu MM, Sugiyama T, Hassan F, Islam S, Mori I, Yoshida T, Yokochi T. Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. 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