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MedKoo Cat#: 413547 | Name: Deptropine maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deptropine maleate is an antihistamine with anticholinergic properties acting at the H1 receptor.

Chemical Structure

Deptropine maleate
Deptropine maleate
CAS#15475-43-1 (maleate)

Theoretical Analysis

MedKoo Cat#: 413547

Name: Deptropine maleate

CAS#: 15475-43-1 (maleate)

Chemical Formula: C27H31NO5

Exact Mass:

Molecular Weight: 449.55

Elemental Analysis: C, 72.14; H, 6.95; N, 3.12; O, 17.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
604-51-3 (free base) 2169-75-7 (citrate) 15475-43-1 (maleate)
Synonym
Deptropine maleate; UNII-N3Y78ZMW6Q
IUPAC/Chemical Name
1-alpha-H,5-alpha-H-Tropane, 3-alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-, maleate (1:1)
InChi Key
RGELJYBIERATBN-WXXVWQJZSA-N
InChi Code
InChI=1S/C23H27NO.C4H4O4/c1-24-18-12-13-19(24)15-20(14-18)25-23-21-8-4-2-6-16(21)10-11-17-7-3-5-9-22(17)23;5-3(6)1-2-4(7)8/h2-9,18-20,23H,10-15H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-,19+,20-;
SMILES Code
[H][C@]12C[C@@H](OC3C4=CC=CC=C4CCC5=CC=CC=C35)C[C@](CC1)(N2C)[H].O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 449.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liang YC, Chang CC, Sheu MT, Lin SY, Chung CC, Teng CT, Suk FM. The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion. Cancers (Basel). 2020 Jun 18;12(6):1610. doi: 10.3390/cancers12061610. PMID: 32570749; PMCID: PMC7352610. 2: Qu C, Li Y, Li Y, Yu P, Li P, Donkers JM, van de Graaf SFJ, de Man RA, Peppelenbosch MP, Pan Q. FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis. Antiviral Res. 2019 Oct;170:104588. doi: 10.1016/j.antiviral.2019.104588. Epub 2019 Aug 12. PMID: 31415805. 3: Cosaert K, Willems L, Spriet I. Le bromure de glycopyrronium, une alternative au citrate de deptropine dans le traitement de la sialorrhée [Glycopyrrolate, an alternative to deptropine citratie when treating sialorrhea]. J Pharm Belg. 2010 Mar;(1):22-3. French. PMID: 20429392. 4: Schirm E, Gebben HJ, Tobi H, de Jong-van den Berg LT. Nog steeds deptropinevoorschriften voor o-4-jarigen [Deptropine still prescribed for 0-4 year olds]. Ned Tijdschr Geneeskd. 2000 Dec 9;144(50):2409-11. Dutch. PMID: 11145097. 5: Cam JF, Gleave CM. A comparison of deptropine citrate (Brontina) with atropine for premedication. Br J Anaesth. 1968 Nov;40(11):885-9. doi: 10.1093/bja/40.11.885. PMID: 4883647. 6: De Bastiani MA, Klamt F. Integrated transcriptomics reveals master regulators of lung adenocarcinoma and novel repositioning of drug candidates. Cancer Med. 2019 Nov;8(15):6717-6729. doi: 10.1002/cam4.2493. Epub 2019 Sep 10. PMID: 31503425; PMCID: PMC6825976. 7: Barber PV, Chatterjee SS, Scott R. A comparison of ipratropium bromide, deptropine citrate and placebo in asthma and chronic bronchitis. Br J Dis Chest. 1977 Apr;71(2):101-4. doi: 10.1016/0007-0971(77)90089-4. PMID: 140698. 8: Wang X, Li S, Ma Y, Xu Y, Ogbuehi AC, Hu X, Acharya A, Haak R, Ziebolz D, Schmalz G, Li H, Gaus S, Lethaus B, Savkovic V, Su Z. Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells. Dis Markers. 2020 Dec 11;2020:6630659. doi: 10.1155/2020/6630659. PMID: 33381243; PMCID: PMC7758130. 9: Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537. PMID: 27894093; PMCID: PMC5352030. 10: LECKIE WJ, HORNE NW. PRELIMINARY ASSESSMENT OF DEPTROPINE DIHYDROGEN CITRATE IN CHRONIC AIRWAYS OBSTRUCTION. Thorax. 1965 Jul;20(4):317-23. doi: 10.1136/thx.20.4.317. PMID: 14321719; PMCID: PMC1018942.