Synonym
Deptropine citrate; BS-6987; BS6987; BS 6987
IUPAC/Chemical Name
1alphaH,5alphaH-Tropane, 3alpha-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)oxy)-,citrate (1:1)
InChi Key
CHQGYMXXKZPWOI-XLMMQIPYSA-N
InChi Code
CHQGYMXXKZPWOI-XLMMQIPYSA-N
SMILES Code
[H][C@]12C[C@@H](OC3C4=CC=CC=C4CCC5=CC=CC=C35)C[C@](CC1)(N2C)[H].OC(C(O)=O)(CC(O)=O)CC(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
525.59
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Qu C, Li Y, Li Y, Yu P, Li P, Donkers JM, van de Graaf SFJ, de Man RA, Peppelenbosch MP, Pan Q. FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis. Antiviral Res. 2019 Oct;170:104588. doi: 10.1016/j.antiviral.2019.104588. Epub 2019 Aug 12. PMID: 31415805.
2: Cui J, Hollmén M, Li L, Chen Y, Proulx ST, Reker D, Schneider G, Detmar M. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022. doi: 10.18632/oncotarget.13537. PMID: 27894093; PMCID: PMC5352030.
3: Cosaert K, Willems L, Spriet I. Le bromure de glycopyrronium, une alternative au citrate de deptropine dans le traitement de la sialorrhée [Glycopyrrolate, an alternative to deptropine citratie when treating sialorrhea]. J Pharm Belg. 2010 Mar;(1):22-3. French. PMID: 20429392.
4: Schirm E, Gebben HJ, Tobi H, de Jong-van den Berg LT. Nog steeds deptropinevoorschriften voor o-4-jarigen [Deptropine still prescribed for 0-4 year olds]. Ned Tijdschr Geneeskd. 2000 Dec 9;144(50):2409-11. Dutch. PMID: 11145097.
5: van Ommen-Koolmees RG, Oudesluys-Murphy AM. Verontrustende toename van intoxicaties door deptropine [Alarming increase in poisonings due to deptoprine]. Ned Tijdschr Geneeskd. 1996 Mar 30;140(13):729. Dutch. PMID: 8668255.
6: Vijlbrief AS, Ponsioen B, de Jongste JC. Verontrustende toename van intoxicaties door deptropine [Alarming increase in deptropine poisonings]. Ned Tijdschr Geneeskd. 1996 Mar 16;140(11):630. Dutch. PMID: 8649534.
7: Griffioen RW. Verontrustende toename van intoxicaties door deptropine [Alarming increase in deptropine poisonings]. Ned Tijdschr Geneeskd. 1996 Mar 16;140(11):629-30. Dutch. PMID: 8649533.
8: Dreijer-van der Glas SM. Verontrustende toename van intoxicaties door deptropine [Alarming increase in deptropine poisonings]. Ned Tijdschr Geneeskd. 1996 Mar 16;140(11):628-9. Dutch. PMID: 8649532.
9: van Zoelen GA, de Vries I, Meulenbelt J. Verontrustende toename van intoxicaties door deptropine [Alarming increase in deptropine poisonings]. Ned Tijdschr Geneeskd. 1996 Jan 13;140(2):98-9. Dutch. PMID: 8569929.
10: de Jonge GA. Consensus astma bij kinderen [Consensus asthma in children]. Ned Tijdschr Geneeskd. 1993 Nov 20;137(47):2446. Dutch. PMID: 8264838.
11: van der Kuy A, Dansz M. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Severe psychological side effects in children due to use of high-dose deptropine]. Ned Tijdschr Geneeskd. 1992 Nov 28;136(48):2388-9. Dutch. PMID: 1461320.
12: van der Laag J, van Aalderen WM, Duiverman EJ, van Essen-Zandvliet EE, Nagelkerke AF, van Nierop JC. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Severe psychological side effect in children using high-dosage detropine]. Ned Tijdschr Geneeskd. 1992 Sep 26;136(39):1925-6. Dutch. PMID: 1407171.
13: Vaessen MH, Koopmans S. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Severe psychological side effects in children using high-dosage deptropine]. Ned Tijdschr Geneeskd. 1992 Sep 26;136(39):1925. Dutch. PMID: 1407170.
14: Griffioen RW. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Severe psychological side effects in children using high-dosage deptropine]. Ned Tijdschr Geneeskd. 1992 Sep 26;136(39):1924-5. Dutch. PMID: 1407169.
15: de Bie JH. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Serious psychological side effects in children due to administration of high dosage deptropine]. Ned Tijdschr Geneeskd. 1992 Aug 8;136(32):1574. Dutch. PMID: 1528292.
16: Stricker BH, Prins AM, Schilte PP. Ernstige psychische bijwerkingen bij kinderen door gebruik van hoge doseringen deptropine [Serious psychological side effect in children taking high doses of deptropine]. Ned Tijdschr Geneeskd. 1992 Jul 11;136(28):1362-5. Dutch. PMID: 1635602.
17: Versteegh FG. Behandeling van astma op de kinderleeftijd [The treatment of asthma in childhood]. Ned Tijdschr Geneeskd. 1988 Jan 9;132(2):85. Dutch. PMID: 3340223.
18: Ruifrok PG. Uptake of quaternary ammonium compounds into rat intestinal brush border membrane vesicles. Biochem Pharmacol. 1981 Oct 1;30(19):2637-41. doi: 10.1016/0006-2952(81)90531-1. PMID: 7197522.
19: Barber PV, Chatterjee SS, Scott R. A comparison of ipratropium bromide, deptropine citrate and placebo in asthma and chronic bronchitis. Br J Dis Chest. 1977 Apr;71(2):101-4. doi: 10.1016/0007-0971(77)90089-4. PMID: 140698.
20: Ripe E. The effect of deptropine citrate aerosol with and without isoprenaline on airway obstruction. Allerg Asthma (Leipz). 1970;16(1):41-52. PMID: 5466222.
