MedKoo Cat#: 413535 | Name: Denzimol Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Denzimol Free Base is an anticonvulsant agent

Chemical Structure

Denzimol Free Base
Denzimol Free Base
CAS#73931-96-1 (free base)

Theoretical Analysis

MedKoo Cat#: 413535

Name: Denzimol Free Base

CAS#: 73931-96-1 (free base)

Chemical Formula: C19H20N2O

Exact Mass: 292.1576

Molecular Weight: 292.38

Elemental Analysis: C, 78.05; H, 6.90; N, 9.58; O, 5.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Denzimol Free Base; CCRIS7525; CCRIS-7525; CCRIS 7525
IUPAC/Chemical Name
(+-)-alpha-(p-Phenethylphenyl)imidazole-1-ethanol
InChi Key
IAWIJHCUEPVIOO-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N2O/c22-19(14-21-13-12-20-15-21)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16/h1-5,8-13,15,19,22H,6-7,14H2
SMILES Code
OC(C1=CC=C(CCC2=CC=CC=C2)C=C1)CN3C=CN=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 292.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Caccia S, Conforti L, Conti I. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat. J Pharm Pharmacol. 1986 Jun;38(6):469-72. doi: 10.1111/j.2042-7158.1986.tb04613.x. PMID: 2873226. 2: Salmona M, Conti I, Testa R, Fracasso C, Caccia S. Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat. J Pharm Pharmacol. 1988 Jan;40(1):17-21. doi: 10.1111/j.2042-7158.1988.tb05142.x. PMID: 2896768. 3: Robertson DW, Krushinski JH, Beedle EE, Leander JD, Wong DT, Rathbun RC. Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol. J Med Chem. 1986 Sep;29(9):1577-86. doi: 10.1021/jm00159a004. PMID: 3746810. 4: Graziani G, Tirone F, Barbadoro E, Testa R. Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. Arzneimittelforschung. 1983;33(8):1155-60. PMID: 6685493. 5: Bertin D, Cova A, Reschiotto C, Tajana A. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. J Chromatogr. 1986 May 28;378(1):147-54. doi: 10.1016/s0378-4347(00)80707-0. PMID: 3733967. 6: Graziani G, Cazzulani P, Luca C, Nava G, Testa R. Denzimol, a new anticonvulsant drug. II. General pharmacological activities. Arzneimittelforschung. 1983;33(8):1161-8. PMID: 6685494. 7: Benassi E, Cocito L, Maffini M, Bo GP, Loeb C. Preliminary note on the effect of denzimol in partial epilepsy. Ital J Neurol Sci. 1988 Aug;9(4):331-5. doi: 10.1007/BF02333995. PMID: 3146556. 8: Ibba M, Vanasia A, Testa R. Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice. Pharmacol Res Commun. 1985 Dec;17(12):1169-80. doi: 10.1016/0031-6989(85)90029-3. PMID: 4095125. 9: Patsalos PN, Alavijeh MS, Brownhill W, Lascelles PT. Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):111-4. doi: 10.1007/BF00169486. PMID: 3368010. 10: Biggiogera M, Barbadoro E, Graziani G, Bernocchi G. Effect of Denzimol, a new anticonvulsant drug, on rat cerebellum. Morphological and histochemical patterns of Purkinje cell layer. Basic Appl Histochem. 1983;27(4):277-90. PMID: 6197058.