|
Solvent |
mg/mL |
mM |
Solubility |
To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
292.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Caccia S, Conforti L, Conti I. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat. J Pharm Pharmacol. 1986 Jun;38(6):469-72. doi: 10.1111/j.2042-7158.1986.tb04613.x. PMID: 2873226.
2: Salmona M, Conti I, Testa R, Fracasso C, Caccia S. Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat. J Pharm Pharmacol. 1988 Jan;40(1):17-21. doi: 10.1111/j.2042-7158.1988.tb05142.x. PMID: 2896768.
3: Robertson DW, Krushinski JH, Beedle EE, Leander JD, Wong DT, Rathbun RC. Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol. J Med Chem. 1986 Sep;29(9):1577-86. doi: 10.1021/jm00159a004. PMID: 3746810.
4: Graziani G, Tirone F, Barbadoro E, Testa R. Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. Arzneimittelforschung. 1983;33(8):1155-60. PMID: 6685493.
5: Bertin D, Cova A, Reschiotto C, Tajana A. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. J Chromatogr. 1986 May 28;378(1):147-54. doi: 10.1016/s0378-4347(00)80707-0. PMID: 3733967.
6: Graziani G, Cazzulani P, Luca C, Nava G, Testa R. Denzimol, a new anticonvulsant drug. II. General pharmacological activities. Arzneimittelforschung. 1983;33(8):1161-8. PMID: 6685494.
7: Benassi E, Cocito L, Maffini M, Bo GP, Loeb C. Preliminary note on the effect of denzimol in partial epilepsy. Ital J Neurol Sci. 1988 Aug;9(4):331-5. doi: 10.1007/BF02333995. PMID: 3146556.
8: Ibba M, Vanasia A, Testa R. Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice. Pharmacol Res Commun. 1985 Dec;17(12):1169-80. doi: 10.1016/0031-6989(85)90029-3. PMID: 4095125.
9: Patsalos PN, Alavijeh MS, Brownhill W, Lascelles PT. Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):111-4. doi: 10.1007/BF00169486. PMID: 3368010.
10: Biggiogera M, Barbadoro E, Graziani G, Bernocchi G. Effect of Denzimol, a new anticonvulsant drug, on rat cerebellum. Morphological and histochemical patterns of Purkinje cell layer. Basic Appl Histochem. 1983;27(4):277-90. PMID: 6197058.