Synonym
Denzimol hydrochloride; REC 15-1533
IUPAC/Chemical Name
alpha-(4-(Phenethyl)phenyl)-1H-imidazol-1-ethanol monohydrochloride
InChi Key
RBDNRYIXZOBPMV-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N2O.ClH/c22-19(14-21-13-12-20-15-21)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16;/h1-5,8-13,15,19,22H,6-7,14H2;1H
SMILES Code
OC(C1=CC=C(CCC2=CC=CC=C2)C=C1)CN3C=CN=C3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tajana A, Sibilia C, Cappelletti R, Cova A, Nardi D. Analytical profile of denzimol hydrochloride new anticonvulsant drug. Boll Chim Farm. 1986 Jan;125(1):7-20. PubMed PMID: 3730178.
2: Graziani G, Tirone F, Barbadoro E, Testa R. Denzimol, a new anticonvulsant drug. I. General anticonvulsant profile. Arzneimittelforschung. 1983;33(8):1155-60. PubMed PMID: 6685493.
3: De Sarro GB, Libri V, Ascioti C, Testa R, Nistico G. Anticonvulsant effect of denzimol in DBA/2 mice. Neuropharmacology. 1987 Sep;26(9):1425-9. PubMed PMID: 3118235.
4: Graziani G, Barbadoro E, Testa R. Denzimol, a new anticonvulsant drug. III. Toxicological evaluation. Arzneimittelforschung. 1983;33(8):1168-73. PubMed PMID: 6685495.
5: Graziani G, Cazzulani P, Luca C, Nava G, Testa R. Denzimol, a new anticonvulsant drug. II. General pharmacological activities. Arzneimittelforschung. 1983;33(8):1161-8. PubMed PMID: 6685494.
6: Bertin D, Cova A, Reschiotto C, Tajana A. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. J Chromatogr. 1986 May 28;378(1):147-54. PubMed PMID: 3733967.
7: Veronese M, Barzaghi D, Bertoncini A, Zadro M. Mutagenicity studies on denzimol, a new anticonvulsant drug. Arzneimittelforschung. 1985;35(5):793-6. PubMed PMID: 3896246.
8: Abbiati GA, Restelli G, Graziani G, Testa R. [HPLC method for the determination of plasma and tissue levels of denzimol hydrochloride]. Boll Chim Farm. 1985 Apr;124(4):178-85. Italian. PubMed PMID: 4041249.
