MedKoo Cat#: 413504 | Name: Delequamine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Delequamine Free Base is used as a selective radioligand for alpha2-adrenoceptors.

Chemical Structure

Delequamine Free Base
Delequamine Free Base
CAS#119905-05-4 (free base)

Theoretical Analysis

MedKoo Cat#: 413504

Name: Delequamine Free Base

CAS#: 119905-05-4 (free base)

Chemical Formula: C18H26N2O3S

Exact Mass: 350.1664

Molecular Weight: 350.48

Elemental Analysis: C, 61.69; H, 7.48; N, 7.99; O, 13.69; S, 9.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Synonym
Delequamine Free Base; RS15385; RS-15385; RS 15385
IUPAC/Chemical Name
(8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine
InChi Key
JKDBLHWERQWYKF-JLSDUUJJSA-N
InChi Code
InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
SMILES Code
COc1cc2c([C@@H]3C[C@H]4[C@@H](CN3CC2)CCCN4S(=O)(C)=O)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 350.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with delequamine (RS15385). Int J Impot Res. 2000 Mar;12 Suppl 1:S64-69. PMID: 10845766. 2: Redfern WS, Williams A. A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br J Pharmacol. 1995 Oct;116(3):2081-9. doi: 10.1111/j.1476-5381.1995.tb16415.x. PMID: 8640349; PMCID: PMC1908953. 3: Tallentire D, McRae G, Spedding M, Clark R, Vickery B. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72. doi: 10.1111/j.1476-5381.1996.tb15367.x. PMID: 8733577; PMCID: PMC1909492. 4: Saenz de Tejada I, Kim NN, Goldstein I, Traish AM. Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. Int J Impot Res. 2000 Mar;12 Suppl 1:S20-25. doi: 10.1038/sj.ijir.3900500. PMID: 10845761. 5: Allard J, Giuliano F. Central nervous system agents in the treatment of erectile dysfunction: how do they work? Curr Urol Rep. 2001 Dec;2(6):488-94. doi: 10.1007/s11934-001-0044-6. PMID: 12084236. 6: Redfern WS, MacLean MR, Clague RU, McGrath JC. The role of alpha 2-adrenoceptors in the vasculature of the rat tail. Br J Pharmacol. 1995 Apr;114(8):1724-30. doi: 10.1111/j.1476-5381.1995.tb14963.x. PMID: 7599941; PMCID: PMC1510371. 7: Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with Delequamine (RS15385). Int J Impot Res. 2000 Mar;12(S1):S64-S69. PMID: 10849567. 8: Gonzalez MI, Patmore L, Wilson CA. Effect of delequamine (RS15385) on female sexual behaviour in the rat. Eur J Pharmacol. 1996 Sep 19;312(1):1-6. doi: 10.1016/0014-2999(96)00445-1. PMID: 8891572. 9: Kim NN, Min K, Huang YH, Goldstein I, Traish AM. Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci. 2002 Nov 1;71(24):2909-20. doi: 10.1016/s0024-3205(02)02162-8. PMID: 12377271. 10: Spedding M, Newman-Tancredi A, Millan MJ, Dacquet C, Michel AN, Jacoby E, Vickery B, Tallentire D. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. 1998 Jun;37(6):769-80. doi: 10.1016/s0028-3908(98)00065-3. PMID: 9707291.