Synonym
Delequamine Free Base; RS15385; RS-15385; RS 15385
IUPAC/Chemical Name
(8aR,12aS,13aS)-3-methoxy-12-(methylsulfonyl)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquinolino[2,1-g][1,6]naphthyridine
InChi Key
JKDBLHWERQWYKF-JLSDUUJJSA-N
InChi Code
InChI=1S/C18H26N2O3S/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3/t14-,17+,18+/m1/s1
SMILES Code
COc1cc2c([C@@H]3C[C@H]4[C@@H](CN3CC2)CCCN4S(=O)(C)=O)cc1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
Solubility |
To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
350.48
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with delequamine (RS15385). Int J Impot Res. 2000 Mar;12 Suppl 1:S64-69. PMID: 10845766.
2: Redfern WS, Williams A. A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br J Pharmacol. 1995 Oct;116(3):2081-9. doi: 10.1111/j.1476-5381.1995.tb16415.x. PMID: 8640349; PMCID: PMC1908953.
3: Tallentire D, McRae G, Spedding M, Clark R, Vickery B. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72. doi: 10.1111/j.1476-5381.1996.tb15367.x. PMID: 8733577; PMCID: PMC1909492.
4: Saenz de Tejada I, Kim NN, Goldstein I, Traish AM. Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. Int J Impot Res. 2000 Mar;12 Suppl 1:S20-25. doi: 10.1038/sj.ijir.3900500. PMID: 10845761.
5: Allard J, Giuliano F. Central nervous system agents in the treatment of erectile dysfunction: how do they work? Curr Urol Rep. 2001 Dec;2(6):488-94. doi: 10.1007/s11934-001-0044-6. PMID: 12084236.
6: Redfern WS, MacLean MR, Clague RU, McGrath JC. The role of alpha 2-adrenoceptors in the vasculature of the rat tail. Br J Pharmacol. 1995 Apr;114(8):1724-30. doi: 10.1111/j.1476-5381.1995.tb14963.x. PMID: 7599941; PMCID: PMC1510371.
7: Bancroft J. Effects of alpha-2 blockade on sexual response: experimental studies with Delequamine (RS15385). Int J Impot Res. 2000 Mar;12(S1):S64-S69. PMID: 10849567.
8: Gonzalez MI, Patmore L, Wilson CA. Effect of delequamine (RS15385) on female sexual behaviour in the rat. Eur J Pharmacol. 1996 Sep 19;312(1):1-6. doi: 10.1016/0014-2999(96)00445-1. PMID: 8891572.
9: Kim NN, Min K, Huang YH, Goldstein I, Traish AM. Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina. Life Sci. 2002 Nov 1;71(24):2909-20. doi: 10.1016/s0024-3205(02)02162-8. PMID: 12377271.
10: Spedding M, Newman-Tancredi A, Millan MJ, Dacquet C, Michel AN, Jacoby E, Vickery B, Tallentire D. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. 1998 Jun;37(6):769-80. doi: 10.1016/s0028-3908(98)00065-3. PMID: 9707291.