Synonym
Hexylcaine HCl; D109; D-109; D 109; cyclaine; osmocaine
IUPAC/Chemical Name
(2-(Benzoyloxy)propyl)cyclohexylammonium chloride
InChi Key
MTFCPNHRBINLRQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H23NO2.ClH/c1-13(12-17-15-10-6-3-7-11-15)19-16(18)14-8-4-2-5-9-14;/h2,4-5,8-9,13,15,17H,3,6-7,10-12H2,1H3;1H
SMILES Code
CC(OC(C1=CC=CC=C1)=O)C[NH2+]C2CCCCC2.[Cl-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
297.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: RUBEN JE, ANDERSON E. Hexylcaine hydrochloride; a preliminary report of its clinical use in comparison with procaine. Am J Surg. 1949 Dec;78(6):843-6. doi: 10.1016/0002-9610(49)90229-9. PMID: 15407013.
2: Li X, Turanli B, Juszczak K, Kim W, Arif M, Sato Y, Ogawa S, Turkez H, Nielsen J, Boren J, Uhlen M, Zhang C, Mardinoglu A. Classification of clear cell renal cell carcinoma based on PKM alternative splicing. Heliyon. 2020 Feb 19;6(2):e03440. doi: 10.1016/j.heliyon.2020.e03440. PMID: 32095654; PMCID: PMC7033363.
3: ANDERSON E, RUBEN JE. Clinical use of cyclaine (hexylcaine hydrochloride) for spinal and regional nerve block: report of 2000 cases. Anesthesiology. 1952 Jul;13(4):429-34. doi: 10.1097/00000542-195207000-00012. PMID: 14943996.
4: AURCURI RA, NEWMAN W, BURSTEIN CL. Electrocardiographic studies during endotracheal intubation. V. Effects during general anesthesia and hexylcaine hydrochloride topical spray. Anesthesiology. 1953 Jan;14(1):46-52. doi: 10.1097/00000542-195301000-00008. PMID: 13017014.
5: Rodgers RM, Dickinson RG, Lynn RK, Gerber N, Loehning RW, Downes H. Studies on the pharmacokinetics of hexylcaine hydrochloride in man and the mouse. Proc West Pharmacol Soc. 1978;21:323-8. PMID: 693515.
6: NEW AND nonofficial remedies: hexylcaine hydrochloride. J Am Med Assoc. 1954 Jul 3;155(10):908-9. PMID: 13162829.
7: Downes H, Hirshman CA, Leon DA. Comparison of local anesthetics as bronchodilator aerosols. Anesthesiology. 1983 Mar;58(3):216-20. doi: 10.1097/00000542-198303000-00002. PMID: 6829955.
8: WHEAT JD. The clinical use of cyclaine (hexylcaine hydrochloride) as a local anesthetic; a preliminary report. J Am Vet Med Assoc. 1952 Feb;120(899):71-2. PMID: 14907521.
9: SPELLBERG MA. Hexylcaine (cyclaine) as topical anesthetic in gastroscopy and esophagoscopy. Gastroenterology. 1959 Jan;36(1):120-1. PMID: 13620024.
10: SASSON L. Comparison of hexylcaine and tetracaine as topical anesthetics in gastroenterologic procedures. N Y State J Med. 1962 Jun 1;62:1808-11. PMID: 14497380.
