MedKoo Cat#: 564582 | Name: FN-439

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FN-439 is a matrix metalloproteinase inhibitor which targets MMP-1 and MMP-9.

Chemical Structure

FN-439
FN-439
CAS#124168-73-6

Theoretical Analysis

MedKoo Cat#: 564582

Name: FN-439

CAS#: 124168-73-6

Chemical Formula: C23H34N6O6

Exact Mass: 490.2540

Molecular Weight: 490.56

Elemental Analysis: C, 56.31; H, 6.99; N, 17.13; O, 19.57

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Related CAS #
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Synonym
NSC727371; NSC-727371; NSC 727371; FN439; FN-439; FN 439; 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
IUPAC/Chemical Name
(2S)-1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[(2R)-1-[[(2R)-1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
InChi Key
WWHUHFFMOPIVKB-OLMNPRSZSA-N
InChi Code
InChI=1S/C23H34N6O6/c1-13(2)11-17(22(33)26-14(3)20(31)28-35)27-23(34)18-5-4-10-29(18)19(30)12-25-21(32)15-6-8-16(24)9-7-15/h6-9,13-14,17-18,35H,4-5,10-12,24H2,1-3H3,(H,25,32)(H,26,33)(H,27,34)(H,28,31)/t14-,17-,18+/m1/s1
SMILES Code
C[C@H](C(=O)NO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)C2=CC=C(C=C2)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 490.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Anan H, Matsumoto A, Hamachi T, Yoshimine Y, Morita Y, Maeda K. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22(12):668-73. PubMed PMID: 9220752.