CUMYL-CBMICA | CAS#N/A | synthetic cannabinoid receptor agonist

MedKoo Cat#: 130208 | Name: CUMYL-CBMICA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CUMYL-CBMICA is a synthetic agonist of the cannabinoid receptor and part of an emerging class of psychoactive substances. CUMYL-CBMICA was found to have a cytotoxic effect and has been shown to be responsible for activating the CB1 receptor.

Chemical Structure

CUMYL-CBMICA

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130208

Name: CUMYL-CBMICA

CAS#: N/A

Chemical Formula: C23H26N2O

Exact Mass: 346.2045

Molecular Weight: 346.47

Elemental Analysis: C, 79.73; H, 7.56; N, 8.09; O, 4.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CUMYL-CBMICA; Cumyl-CBMICA; CUMYL CBMICA; SGT-280; SGT280; SGT 280

IUPAC/Chemical Name

1-(cyclobutylmethyl)-N-(2-phenylpropan-2-yl)-1H-indole-3-carboxamide

InChi Key

INXXQNIOWMOYEJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H26N2O/c1-23(2,18-11-4-3-5-12-18)24-22(26)20-16-25(15-17-9-8-10-17)21-14-7-6-13-19(20)21/h3-7,11-14,16-17H,8-10,15H2,1-2H3,(H,24,26)

SMILES Code

O=C(C1=CN(CC2CCC2)C3=C1C=CC=C3)NC(C)(C4=CC=CC=C4)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 346.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Pulver B, Riedel J, Schönberger T, Halter S, Lucas T, Opatz T, Grafinger KE, Scheu M, Zschiesche A, Pütz M, Pützer K, Westphal F, Auwärter V. Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl- and norbornylmethyl-type synthetic cannabinoid receptor agonists. Drug Test Anal. 2022 Dec 21. doi: 10.1002/dta.3427. Epub ahead of print. PMID: 36541839. 2. Janssens LK, Ametovski A, Sparkes E, Boyd R, Lai F, Maloney CJ, Rhook D, Gerona RR, Connolly M, Liu H, Hibbs DE, Cairns EA, Banister SD, Stove CP. Comprehensive Characterization of a Systematic Library of Alkyl and Alicyclic Synthetic Cannabinoids Related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA. ACS Chem Neurosci. 2023 Jan 4;14(1):35-52. doi: 10.1021/acschemneuro.2c00408. Epub 2022 Dec 18. PMID: 36530139. 3. Gampfer TM, Wagmann L, Pulver B, Westphal F, Flockerzi V, Meyer MR. A simplified strategy to assess the cytotoxicity of new psychoactive substances in HepG2 cells using a high content screening assay - Exemplified for nine compounds. Toxicology. 2022 Jun 30;476:153258. doi: 10.1016/j.tox.2022.153258. Epub 2022 Jul 13. PMID: 35842060. 4. Haschimi B, Grafinger KE, Pulver B, Psychou E, Halter S, Huppertz LM, Westphal F, Pütz M, Auwärter V. New synthetic cannabinoids carrying a cyclobutyl methyl side chain: Human Phase I metabolism and data on human cannabinoid receptor 1 binding and activation of Cumyl-CBMICA and Cumyl-CBMINACA. Drug Test Anal. 2021 Aug;13(8):1499-1515. doi: 10.1002/dta.3038. Epub 2021 May 5. PMID: 33788409. 5. Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, Ellison R, Gerona R, Banister SD, Stove CP. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA. ACS Chem Neurosci. 2020 Dec 16;11(24):4434-4446. doi: 10.1021/acschemneuro.0c00644. Epub 2020 Nov 30. PMID: 33253529. 6. Halter S, Pulver B, Wilde M, Haschimi B, Westphal F, Riedel J, Pütz M, Schönberger T, Stoll S, Schäper J, Auwärter V. Cumyl-CBMICA: A new synthetic cannabinoid receptor agonist containing a cyclobutyl methyl side chain. Drug Test Anal. 2021 Jan;13(1):208-216. doi: 10.1002/dta.2942. Epub 2020 Oct 23. PMID: 33037749.