Synonym
CV 5975; CV5975; CV-5975
IUPAC/Chemical Name
3-(1-Carboxy-5-(4-piperidyl)pentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid
InChi Key
VGLXNWGVKZBOQS-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H31N3O5S/c26-20(27)13-25-18-7-3-4-8-19(18)31-14-17(21(25)28)24-16(22(29)30)6-2-1-5-15-9-11-23-12-10-15/h3-4,7-8,15-17,23-24H,1-2,5-6,9-14H2,(H,26,27)(H,29,30)
SMILES Code
O=C(O)CN1C(C(NC(C(O)=O)CCCCC2CCNCC2)CSC3=CC=CC=C13)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
449.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Inada Y, Tanabe M, Kawazoe K, Nishikawa K. Antihypertensive action of a new angiotensin converting enzyme inhibitor, (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5-tetr ahy dro-1,5-benzothiazepine-5-acetic acid (CV-5975), in various hypertensive models. Jpn J Pharmacol. 1988 Jul;47(3):311-22. doi: 10.1254/jjp.47.311. PMID: 2851677.
2: Inada Y, Tanabe M, Itoh K, Sugihara H, Nishikawa K. Inhibition of angiotensin converting enzyme by (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5-tetra- hydro-1,5-benzothiazepine-6-acetic acid (CV-5975), a non-sulfhydryl compound. Jpn J Pharmacol. 1988 Nov;48(3):323-30. doi: 10.1254/jjp.48.323. PMID: 2851678.
3: Inada Y, Itoh K, Kamiya K, Sugihara H, Nishikawa K. (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5- tetrahydro-1,5-benzothiazepine-5-acetic acid (CV-5975): a new potent and long- lasting inhibitor of angiotensin converting enzyme. Jpn J Pharmacol. 1988 Jun;47(2):135-41. doi: 10.1254/jjp.47.135. PMID: 3199591.
4: Kori M, Itoh K, Sugihara H. An improved synthesis of the new angiotensin converting enzyme inhibitor CV-5975 via a chemoenzymatic process. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2319-26. doi: 10.1248/cpb.35.2319. PMID: 3664829.
