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MedKoo Cat#: 318679 | Name: Rosoxacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rosoxacin is a quinolone antibiotic indicated for the treatment of urinary tract infections and certain sexually transmitted diseases. It was developed by Sanofi-Synthelabo.

Chemical Structure

Rosoxacin
Rosoxacin
CAS# 40034-42-2

Theoretical Analysis

MedKoo Cat#: 318679

Name: Rosoxacin

CAS#: 40034-42-2

Chemical Formula: C17H14N2O3

Exact Mass: 294.1004

Molecular Weight: 294.30

Elemental Analysis: C, 69.38; H, 4.79; N, 9.52; O, 16.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rosoxacin; Acrosoxacin; Eradacil; Winuron; Roxadyl; Rosoxacine; Eradacin; rosoxacin; Win 35,213;
IUPAC/Chemical Name
1-ethyl-4-oxo-7-pyridin-4-ylquinoline-3-carboxylic acid
InChi Key
XBPZXDSZHPDXQU-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
SMILES Code
CCN1C=C(C(=O)C2=C1C=C(C=C2)C3=CC=NC=C3)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 294.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vagaskar SR, Fernandez RJ, Wagle UD, Rajani ND. Rosoxacin in the treatment of uncomplicated acute gonococcal urethritis. J Postgrad Med. 1990 Oct;36(4):191-3. PubMed PMID: 1966732. 2: Bhujwala RA, Bhargava NC, Biswas TD, Narain S, Pandhi RK. Antimicrobial sensitivity of Neisseria gonorrhoeae to spectinomycin & rosoxacin. Indian J Med Res. 1987 Dec;86:702-6. PubMed PMID: 2967246. 3: Habte-Gabr E, Geyid A, Serdo D, Biddle J, Perine PL. Single-dose treatment of uncomplicated acute gonococcal urethritis in Ethiopian men: comparison of rosoxacin, spectinomycin, penicillin, and ampicillin. Sex Transm Dis. 1987 Jul-Sep;14(3):153-5. PubMed PMID: 2958947. 4: Stapiński A, Dajek Z, Mroczkowski TF, Gede K, Jagielski M, Selibórska Z. [Rosoxacin, a new oral antibiotic used selectively in the treatment of gonorrhea]. Przegl Dermatol. 1987 May-Jun;74(3):223-8. Polish. PubMed PMID: 3122279. 5: Digranes A, Dibb WL, Benonisen E. In vitro activities of ciprofloxacin, ofloxacin, norfloxacin and rosoxacin compared with cinoxacin and trimethoprim. Chemotherapy. 1985;31(6):466-71. PubMed PMID: 2934234. 6: Panikabutra K, Ariyarit C, Chitwarakorn A, Saensanoh C. Rosoxacin in the treatment of uncomplicated gonorrhoea in men. Br J Vener Dis. 1984 Aug;60(4):231-4. PubMed PMID: 6234966; PubMed Central PMCID: PMC1046315. 7: Lim KB, Rajan VS, Giam YC, Lui EO, Sng EH, Yeo KL. Treatment of uncomplicated gonorrhoea with rosoxacin (acrosoxacin). Br J Vener Dis. 1984 Jun;60(3):157-60. PubMed PMID: 6428698; PubMed Central PMCID: PMC1046290. 8: Dickgiesser N, Kuntz P. The activity of rosoxacin, fosfomycin, cefotiam, and spectinomycin on beta-lactamase producing Neisseria gonorrhoeae. Br J Vener Dis. 1984 Jun;60(3):154-6. PubMed PMID: 6329404; PubMed Central PMCID: PMC1046289. 9: Mason PR, Latif AS, Gundiza MG. Disc sensitivity of gonococci to rosoxacin, tetracycline and beta-lactam antibiotics. Cent Afr J Med. 1983 Nov;29(11):216-7. PubMed PMID: 6423286. 10: Soussy CJ, Le Van Thoi J, Chanal M, Cluzel M, Fleurette J, Forey F, Thabaut A, Meyran M, Vandekerkove M, Sicard D, Acar JF, Kitzis MD, Veron M, Fauchere JL. [In vitro effect of rosoxacin on hospital bacteria. Results of a multicenter study]. Pathol Biol (Paris). 1983 Jun;31(6):504-8. French. PubMed PMID: 6348657. 11: Maurel DL, Fanproyen G, Alfei LB, Levalle S, Vacchino M. [Efficacy and tolerability of single-dose rosoxacin in the treatment of acute uncomplicated gonorrhea]. Sem Hop. 1982 Nov 4;58(40):2331-7. French. PubMed PMID: 6297015. 12: Lucon AM, Glina S, Wroclawski ER, Borrelli M, de Góes GM. [Gonococcal urethritis--treatment with rosoxacin]. Rev Hosp Clin Fac Med Sao Paulo. 1982 Aug;37(4):183-5. Portuguese. PubMed PMID: 6763313. 13: Calubiran OV, Crisologo-Vizconde LB, Tupasi TE, Torres CA, Limson BM. Treatment of uncomplicated gonorrhoea in women. Comparison of rosoxacin and spectinomycin. Br J Vener Dis. 1982 Aug;58(4):231-5. PubMed PMID: 6213287; PubMed Central PMCID: PMC1046055. 14: Hulem CD, Old SE, Zeleznick LD, Leopold IH. Intraocular penetration of rosoxacin in rabbits. Arch Ophthalmol. 1982 Apr;100(4):646-9. PubMed PMID: 7073586. 15: Jensen KM, Patel RB, Welling PG, Madsen PO. Human prostatic tissue concentrations of rosoxacin. Prostate. 1982;3(5):523-9. PubMed PMID: 7145776. 16: Limson BM, Macasaet RK. Single oral dose rosoxacin in the treatment of gonorrhoea in males. J Int Med Res. 1982;10(1):42-5. PubMed PMID: 6800861. 17: Handsfield HH, Judson FN, Holmes KK. Treatment of uncomplicated gonorrhea with rosoxacin. Antimicrob Agents Chemother. 1981 Nov;20(5):625-9. PubMed PMID: 6798924; PubMed Central PMCID: PMC181763. 18: Goh CL, Rajan VS. Re: Rosoxacin (trade name Eradacil) for the treatment of gonorrhoea. Singapore Med J. 1981 Aug;22(4):247. PubMed PMID: 7323835. 19: Mahendran R, Jayakuru GN. Antibiotic resistance in gonorrhoea with special reference to rosoxacin in the treatment of a multi-resistant case. Ceylon Med J. 1981 Jun;26(2):94-8. PubMed PMID: 6821032. 20: Seth AD. Sensitivity of gonococci to rosoxacin compared with that of penicillin, cefuroxime and tetracycline. J Antimicrob Chemother. 1981 Apr;7(4):331-4. PubMed PMID: 6788746.

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JNJ-1013

JNJ-1013