Sinomenine HCl | CAS# 6080-33-7 (HCl) | activator of μ-opioid receptor

MedKoo Cat#: 413376 | Name: Sinomenine hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sinomenine hydrochloride is an alkaloid derived from the plant Sinomenium acutum, commonly used in traditional Chinese medicine. It exhibits anti-inflammatory, immunosuppressive, and analgesic properties, primarily through inhibition of NF-κB signaling and suppression of pro-inflammatory cytokine production. Sinomenine hydrochloride is often used to manage conditions such as rheumatoid arthritis and other inflammatory disorders.

Chemical Structure

Sinomenine hydrochloride

CAS#6080-33-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 413376

Name: Sinomenine hydrochloride

CAS#: 6080-33-7 (HCl)

Chemical Formula: C19H24ClNO4

Exact Mass: 0.0000

Molecular Weight: 365.85

Elemental Analysis: C, 62.38; H, 6.61; Cl, 9.69; N, 3.83; O, 17.49

Price and Availability

Size	Price	Availability	Quantity
1g	USD 350.00	2 Weeks
5g	USD 650.00	2 Weeks

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Related CAS #

115-53-7 (free base) 6080-33-7 (HCl)

Synonym

Cucoline HCl; NSC76021; NSC-76021; NSC 76021; Sinomenine hydrochloride; Kukolin hydrochloride

IUPAC/Chemical Name

9-alpha,13-alpha,14-alpha-Morphinan-6-one, 7,8-didehydro-3,7-dimethoxy-4-hydroxy-17-methyl-, hydrochloride

InChi Key

YMEVIMJAUHZFMW-QQKODRLFSA-N

InChi Code

InChI=1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13-,19+;/m0./s1

SMILES Code

[H][C@]1([C@@]2(C3)C4=C(O)C(OC)=CC=C4C[C@]1([H])N(C)CC2)C=C(OC)C3=O.[H]Cl

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 365.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhu L, Chen J, Liu Y, Chen W, Liu X, Yang F. Modulation of Prostaglandin- Endoperoxide Synthase 1 by Caulis Sinomenii: A Novel Approach to Alleviating Diabetic Peripheral Neuropathy Through Apoptosis Inhibition and Anti- inflammatory Effects. ACS Chem Neurosci. 2025 Jun 16. doi: 10.1021/acschemneuro.5c00226. Epub ahead of print. PMID: 40522695. 2: Xu C, Zhao X, Niu Z, Wang Y, Jiang X, Tian J, Feng Y, Huang X, Tian P. Comparative efficacy of Naringenin and Sinomenine in facilitating the differentiation of mouse hematopoietic stem cells into immature dendritic cells to promote transplantation immunological regulation. Transpl Immunol. 2025 Jun 9;92:102260. doi: 10.1016/j.trim.2025.102260. Epub ahead of print. PMID: 40499621. 3: Du Y, Bai J, Ma T, Wu Z, Wang P, Zhong X, Fu W, He S. Sinomenine Ameliorates Liver Fibrosis by Blocking TGF-β/SMAD and c-JUN Signaling. Phytother Res. 2025 Jun 1. doi: 10.1002/ptr.8502. Epub ahead of print. PMID: 40452107. 4: Song D, Khan A, Dong MH, Lei CW, Feng TT, Zhou Y, Wei X. Anti-Inflammatory Mechanism Prediction of Sinomenine Based on Network Pharmacology and Its Biological Activity Verification. Biology (Basel). 2025 May 13;14(5):543. doi: 10.3390/biology14050543. PMID: 40427732; PMCID: PMC12109165. 5: Zhang S, Tan H, Zhang Z, Wang Z, Zhang C, Zhang J, Jia E. Sinomenine alleviates gouty inflammation by inhibiting macrophage M1 polarization and neutrophil extracellular trap formation. Naunyn Schmiedebergs Arch Pharmacol. 2025 May 17. doi: 10.1007/s00210-025-04161-4. Epub ahead of print. PMID: 40381009. 6: Cui M, Li W, Liu L, Chen Y, Liu H, Ji M, Yang F, Wang P. Sulfatase-mediated peroxidase-like activity: A chemiluminescence-based platform for high-throughput screening of natural inhibitors in cancer therapy. Biosens Bioelectron. 2025 Sep 15;284:117562. doi: 10.1016/j.bios.2025.117562. Epub 2025 May 8. PMID: 40373529. 7: Wang Y, Li M, Yu X, Chen A, Ding Y, Wang Y, Wang Y. [Retracted] Sinomenine hydrochloride inhibits cell survival in human hepatoma Huh7 cells. Biomed Rep. 2025 Apr 28;23(1):106. doi: 10.3892/br.2025.1984. PMID: 40364905; PMCID: PMC12070148. 8: Zheng YZ, Kong Y, Zhuo FF, Shen Y, Wang YQ, Yang Z, Wang T, Yu SM, Li L, Yu M, Wei TT, Liu D, Xu LZ, Han B, Liu F, Xu Z, Zeng KW, Tu PF. Discovery of sinomenine derivatives inhibiting macrophage polarization against rheumatoid arthritis through selectively targeting heme oxygenase-1. Eur J Med Chem. 2025 Aug 5;292:117596. doi: 10.1016/j.ejmech.2025.117596. Epub 2025 Apr 2. PMID: 40328036. 9: Luo X, Niu JY, Chen HS. The potential value of traditional Chinese medicine monomers in cerebral ischemia-reperfusion injury: a network meta-analysis based on animal model. BMC Complement Med Ther. 2025 May 5;25(1):163. doi: 10.1186/s12906-025-04899-7. PMID: 40325432; PMCID: PMC12051284. 10: Tang J, Li S, Wang Y, Yuan M, Wan Y, Liang X, Guo L, Guo Y. Study of Folate- Modified Carboxymethyl Chitosan-Sinomenine-Curcumin Nanopolymer for Targeted Treatment of Rheumatoid Arthritis. Biomacromolecules. 2025 Jun 9;26(6):3291-3308. doi: 10.1021/acs.biomac.4c01701. Epub 2025 May 5. PMID: 40324022. 11: He Y, Huang H, Li G, Zhang Y, He J, Lin Y, Wu F, Yan J, Cai X, Liu L. Safety Profile, Toxicokinetic, and Intestinal Absorption Differences of a Naturally- Derived Anti-Rheumatic Drug, Sinomenine Hydrochloride, in Normal and Arthritic Rats. Pharmaceutics. 2025 Apr 7;17(4):484. doi: 10.3390/pharmaceutics17040484. PMID: 40284479; PMCID: PMC12030057. 12: Zhang Z, Ma X, Pan W, Li X, Li Y, Fang N, Yin X, Yang L, Hou Q, Yang D, Ji T, Zheng R, Lin M. A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. J Med Chem. 2025 May 8;68(9):9723-9740. doi: 10.1021/acs.jmedchem.5c00546. Epub 2025 Apr 17. PMID: 40243551. 13: Lu H, Zeng F, Gong H, Du J, Gao W, Xu J, Cai X, Yang Y, Xiao H. Sinomenine Inhibits TOPK To Ameliorate Psoriasiform Dermatitis. ACS Omega. 2025 Mar 24;10(13):13537-13547. doi: 10.1021/acsomega.5c00336. PMID: 40224460; PMCID: PMC11983351. 14: Jiang H, Lu Q, Huang X, Zhang H, Zeng J, Wang M, Xu J, Yuan Z, Wei Q, Xiao E, Wang P, Huang G, Xu A. Sinomenine-glycyrrhizic acid self-assembly enhanced the anti-inflammatory effect of sinomenine in the treatment of rheumatoid arthritis. J Control Release. 2025 Jun 10;382:113718. doi: 10.1016/j.jconrel.2025.113718. Epub 2025 Apr 10. PMID: 40220871. 15: Tang Z, Yu F, Peng Z, Gao N, Liao Z, Zhao S, Xia Y, Fu H, Zhong S, Long W, He Z. Sinomenine ameliorates vascular calcification by inhibiting pyroptosis- related molecules and AEG-1 in chronic kidney disease. Eur J Pharmacol. 2025 Jun 5;996:177594. doi: 10.1016/j.ejphar.2025.177594. Epub 2025 Apr 3. PMID: 40187593. 16: Gao Q, Peng J, Xiong M, Zhou S, Wang X, Lu J, Guo Y, Peng Q, Zeng M, Song H. Sinomenine alleviates experimental autoimmune uveitis in rats: Possible involvement of PI3K/AKT and NF-κB signaling pathways. Eur J Pharmacol. 2025 Jun 5;996:177571. doi: 10.1016/j.ejphar.2025.177571. Epub 2025 Apr 1. PMID: 40180267. 17: Guo MQ, Hu P, Huang ZW. Cyclodextrin host-guest complex to facilitate sinomenine-based osteoporosis therapy. World J Stem Cells. 2025 Mar 26;17(3):101376. doi: 10.4252/wjsc.v17.i3.101376. PMID: 40160693; PMCID: PMC11947896. 18: Hua P, Yang S, Yu L, Huang Y, Chen M. Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression. Biomater Sci. 2025 Apr 29;13(9):2462-2474. doi: 10.1039/d5bm00036j. PMID: 40146040. 19: Yuan Z, Zhao X, Zhang Y, Jiao Y, Liu Y, Gao C, Zhang J, Ma Y, Wang Z, Li T. Using Integrated Network Pharmacology and Metabolomics to Reveal the Mechanisms of the Combined Intervention of Ligustrazine and Sinomenine in CCI-Induced Neuropathic Pain Rats. Int J Mol Sci. 2025 Mar 13;26(6):2604. doi: 10.3390/ijms26062604. PMID: 40141247; PMCID: PMC11942381. 20: Xu P, Sun F, Lin X, Wang L, Jiang L, Chen S, Hu C. An Off-On Fluorescent Probe Reveals Spatiotemporal Signaling of Opioid Receptors In Vivo for Pain Control. Anal Chem. 2025 Apr 8;97(13):7148-7156. doi: 10.1021/acs.analchem.4c06446. Epub 2025 Mar 26. PMID: 40139901.

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CAS#: 138778-28-6