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MedKoo Cat#: 413330 | Name: Sunepitron Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sunepitron Free Base is a combined 5-HT1A receptor agonist and α₂-adrenergic receptor antagonist. It was previously under development by Pfizer for the treatment of depression and anxiety. It made it to phase III clinical trials before being discontinued.

Chemical Structure

Sunepitron Free Base
Sunepitron Free Base
CAS#131831-03-3 (free base)

Theoretical Analysis

MedKoo Cat#: 413330

Name: Sunepitron Free Base

CAS#: 131831-03-3 (free base)

Chemical Formula: C17H23N5O2

Exact Mass: 329.1852

Molecular Weight: 329.40

Elemental Analysis: C, 61.99; H, 7.04; N, 21.26; O, 9.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
148408-65-5 (HCl) 131831-03-3 (free base)
Synonym
Sunepitron Free Base; CP93,393; CP 93,393; CP-93,393
IUPAC/Chemical Name
2,5-Pyrrolidinedione, 1-(((7S,9aS)-octahydro-2-(2-pyrimidinyl)-2H-pyrido(1,2-a)pyrazin-7-yl)methyl)-
InChi Key
UXWBIYCPUVWKHP-KBPBESRZSA-N
InChi Code
InChI=1S/C17H23N5O2/c23-15-4-5-16(24)22(15)11-13-2-3-14-12-21(9-8-20(14)10-13)17-18-6-1-7-19-17/h1,6-7,13-14H,2-5,8-12H2/t13-,14-/m0/s1
SMILES Code
O=C(CC1)N(C[C@H]2CC[C@@]3([H])CN(C4=NC=CC=N4)CCN3C2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 329.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Colgan ST, Dumont ML, Ruggeri SG. Assay and purity evaluation of sunepitron hydrochloride by reversed-phase liquid chromatography using a reference standard composite. J Pharm Biomed Anal. 1998 Nov;18(3):429-40. doi: 10.1016/s0731-7085(98)00057-0. PMID: 10096837. 2: Goodnick PJ. Psychopharmacology of depression in the next millennium. CNS Spectr. 1999 Jul;4(7):21-35. doi: 10.1017/s1092852900011998. PMID: 18438295. 3: Ahsan ZS, Song Y, Yao J. Outcomes of ulnar shortening osteotomy fixed with a dynamic compression system. J Hand Surg Am. 2013 Aug;38(8):1520-3. doi: 10.1016/j.jhsa.2013.04.040. Epub 2013 Jul 3. PMID: 23830678. 4: Spell JC, Stewart JT. Analysis of clonazepam in a tablet dosage form using smallbore HPLC. J Pharm Biomed Anal. 1998 Nov;18(3):453-60. doi: 10.1016/s0731-7085(98)00058-2. PMID: 10096839. 5: Hambire SD, Bhavsar PP, B M, Jayakar AV. Fraser-Cryptophthalmos syndrome with cardiovascular malformations: a rare association. Indian Pediatr. 2003 Sep;40(9):888-90. PMID: 14530551.

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