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MedKoo Cat#: 413315 | Name: CP 31398 Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP 31398 Free Base is a prototype small molecule that stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

Chemical Structure

CP 31398 Free Base
CP 31398 Free Base
CAS#259199-65-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413315

Name: CP 31398 Free Base

CAS#: 259199-65-0 (free base)

Chemical Formula: C22H26N4O

Exact Mass: 362.2107

Molecular Weight: 362.48

Elemental Analysis: C, 72.90; H, 7.23; N, 15.46; O, 4.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
259199-65-0 (free base) 1217195-61-3 (2HCl)
Synonym
CP 31398 Free Base; CP31398; CP-31398
IUPAC/Chemical Name
(E)-N1-(2-(4-methoxystyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine
InChi Key
NIHSNFSFDGHHRG-SDNWHVSQSA-N
InChi Code
InChI=1S/C22H26N4O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
SMILES Code
CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 362.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu L, Yang L, Chang H, Chen YN, Zhang F, Feng S, Peng J, Ren CC, Zhang XA. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. Int J Oncol. 2019 Mar;54(3):942-954. doi: 10.3892/ijo.2019.4681. Epub 2019 Jan 9. PMID: 30628640; PMCID: PMC6365028. 2: Liu L, Yu TT, Ren CC, Yang L, Cui SH, Zhang XA. CP-31398 inhibits the progression of cervical cancer through reversing the epithelial mesenchymal transition via the downregulation of PAX2s. J Cell Physiol. 2019 Mar;234(3):2929-2942. doi: 10.1002/jcp.27109. Epub 2018 Aug 21. PMID: 30132866. 3: Zhong B, Shingyoji M, Hanazono M, Nguyễn TTT, Morinaga T, Tada Y, Hiroshima K, Shimada H, Tagawa M. A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway. Am J Cancer Res. 2019 Jan 1;9(1):79-93. PMID: 30755813; PMCID: PMC6356922. 4: Wu JT, Lin CL, Huang CJ, Cheng YC, Chien CC, Sung YC. Potential synergistic effects of sorafenib and CP-31398 for treating anaplastic thyroid cancer with p53 mutations. Oncol Lett. 2020 Apr;19(4):3021-3026. doi: 10.3892/ol.2020.11377. Epub 2020 Feb 7. PMID: 32218859; PMCID: PMC7068379. 5: He XX, Zhang YN, Yan JW, Yan JJ, Wu Q, Song YH. CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo. Tumour Biol. 2016 Jan;37(1):807-15. doi: 10.1007/s13277-015-3857-5. Epub 2015 Aug 7. PMID: 26250460. 6: He X, Kong X, Yan J, Yan J, Zhang Y, Wu Q, Chang Y, Shang H, Dou Q, Song Y, Liu F. CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo. Tumour Biol. 2015 Mar;36(3):1437-44. doi: 10.1007/s13277-014-2389-8. Epub 2015 Feb 8. PMID: 25663456. 7: Zhong B, Shingyoji M, Hanazono M, Nguyễn TT, Morinaga T, Tada Y, Shimada H, Hiroshima K, Tagawa M. Combination of a p53-activating CP-31398 and an MDM2 or a FAK inhibitor produces growth suppressive effects in mesothelioma with wild-type p53 genotype. Apoptosis. 2020 Aug;25(7-8):535-547. doi: 10.1007/s10495-020-01612-6. PMID: 32468177. 8: Arihara Y, Takada K, Kamihara Y, Hayasaka N, Nakamura H, Murase K, Ikeda H, Iyama S, Sato T, Miyanishi K, Kobune M, Kato J. Small molecule CP-31398 induces reactive oxygen species-dependent apoptosis in human multiple myeloma. Oncotarget. 2017 Jul 22;8(39):65889-65899. doi: 10.18632/oncotarget.19508. PMID: 29029480; PMCID: PMC5630380. 9: Liu L, Yu ZY, Yu TT, Cui SH, Yang L, Chang H, Qu YH, Lv XF, Zhang XA, Ren CC. A Slug-dependent mechanism is responsible for tumor suppression of p53-stabilizing compound CP-31398 in p53-mutated endometrial carcinoma. J Cell Physiol. 2020 Nov;235(11):8768-8778. doi: 10.1002/jcp.29720. Epub 2020 Jul 6. PMID: 32633026. 10: Tanner S, Barberis A. CP-31398, a putative p53-stabilizing molecule tested in mammalian cells and in yeast for its effects on p53 transcriptional activity. J Negat Results Biomed. 2004 Nov 17;3:5. doi: 10.1186/1477-5751-3-5. PMID: 15548325; PMCID: PMC534789.