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MedKoo Cat#: 565240 | Name: CP-31398 Dihydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

Chemical Structure

CP-31398 Dihydrochloride
CP-31398 Dihydrochloride
CAS#1217195-61-3 (2HCl)

Theoretical Analysis

MedKoo Cat#: 565240

Name: CP-31398 Dihydrochloride

CAS#: 1217195-61-3 (2HCl)

Chemical Formula: C22H28Cl2N4O

Exact Mass: 434.1640

Molecular Weight: 435.39

Elemental Analysis: C, 60.69; H, 6.48; Cl, 16.28; N, 12.87; O, 3.67

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
259199-65-0 (free base) 1217195-61-3 (2HCl)
Synonym
CP31398 dihydrochloride; CP 31398 dihydrochloride; CP-31398 dihydrochloride
IUPAC/Chemical Name
N-[2-[(E)-2-(4-Methoxyphenyl)ethenyl]quinazolin-4-yl]-N',N'-dimethylpropane-1,3-diamine dihydrochloride
InChi Key
WWIFDJIOGCGSBS-IVKCLRODSA-N
InChi Code
InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;
SMILES Code
CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 435.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fujiwara T, Morimoto K. A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration. Biochem Biophys Res Commun. 2013 Oct 25;440(3):359-63. doi: 10.1016/j.bbrc.2013.08.052. Epub 2013 Aug 26. PubMed PMID: 23988450. 2: Johnson WD, Muzzio M, Detrisac CJ, Kapetanovic IM, Kopelovich L, McCormick DL. Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology. 2011 Nov 18;289(2-3):141-50. doi: 10.1016/j.tox.2011.08.009. Epub 2011 Aug 16. PubMed PMID: 21864638; PubMed Central PMCID: PMC3195508.