Synonym
Milacemide; CP1552 S; CP-1552 S; CP 1552 S
IUPAC/Chemical Name
Acetamide, 2-(pentylamino)-
InChi Key
GJNNXIYZWIZFRH-UHFFFAOYSA-N
InChi Code
InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)
SMILES Code
O=C(N)CNCCCCC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
144.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.Milacemide, a glycine pro-drug, inhibits strychnine-allodynia without affecting normal nociception in the rat.
Khandwala H, Loomis CW.
Pain. 1998 Jul;77(1):87-95. doi: 10.1016/S0304-3959(98)00086-4.
PMID: 9755023
2.Milacemide enhances memory storage and alleviates spontaneous forgetting in mice.
Quartermain D, Nuygen T, Sheu J, Herting RL.
Pharmacol Biochem Behav. 1991 May;39(1):31-5. doi: 10.1016/0091-3057(91)90393-g.
PMID: 1833781
3.Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells.
Godfraind JM.
Br J Pharmacol. 1990 May;100(1):119-25. doi: 10.1111/j.1476-5381.1990.tb12062.x.
PMID: 2196964 Free PMC article.
4.Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type.
Dysken MW, Mendels J, LeWitt P, Reisberg B, Pomara N, Wood J, Skare S, Fakouhi JD, Herting RL.
J Am Geriatr Soc. 1992 May;40(5):503-6. doi: 10.1111/j.1532-5415.1992.tb02019.x.
PMID: 1634705 Clinical Trial.
5.Milacemide and other drugs active at glutamate NMDA receptors as potential treatment for dementia.
Herting RL.
Ann N Y Acad Sci. 1991;640:237-40. doi: 10.1111/j.1749-6632.1991.tb00225.x.
PMID: 1837978 Clinical Trial.
6.The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B.
Janssens de Varebeke P, Pauwels G, Buyse C, David-Remacle M, De Mey J, Roba J, Youdim MB.
J Neurochem. 1989 Oct;53(4):1109-16. doi: 10.1111/j.1471-4159.1989.tb07403.x.
PMID: 2769256
7.Formation of the neurotransmitter glycine from the anticonvulsant milacemide is mediated by brain monoamine oxidase B.
Janssens de Varebeke P, Cavalier R, David-Remacle M, Youdim MB.
J Neurochem. 1988 Apr;50(4):1011-6. doi: 10.1111/j.1471-4159.1988.tb10566.x.
PMID: 3346666
8.Cognitive effects of milacemide and methylphenidate in healthy young adults.
Camp-Bruno JA, Herting RL.
Psychopharmacology (Berl). 1994 Jun;115(1-2):46-52. doi: 10.1007/BF02244750.
PMID: 7862911 Clinical Trial.
9.Is the oxidation of milacemide by monoamine oxidase a major factor in its anticonvulsant actions?
O'Brien EM, Tipton KF, Strolin Benedetti M, Bonsignori A, Marrari P, Dostert P.
Biochem Pharmacol. 1991 Jun 1;41(11):1731-7. doi: 10.1016/0006-2952(91)90177-7.
PMID: 2043162
10.Species differences in the interactions of the anticonvulsant milacemide and some analogues with monoamine oxidase-B.
O'Brien EM, Dostert P, Tipton KF.
Biochem Pharmacol. 1995 Jul 31;50(3):317-24. doi: 10.1016/0006-2952(95)00145-p.
PMID: 7646533
