Milacemide HCl | CAS#76990-85-7 (HCl) | MAO-B inhibitor

MedKoo Cat#: 562681 | Name: Milacemide HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milacemide HCl is a MAO-B inhibitor and glycine prodrug. It is currently being studied as a treatment for the symptoms of Alzheimer's disease.

Chemical Structure

Milacemide HCl

CAS#76990-85-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 562681

Name: Milacemide HCl

CAS#: 76990-85-7 (HCl)

Chemical Formula: C7H17ClN2O

Exact Mass:

Molecular Weight: 180.67

Elemental Analysis: C, 46.53; H, 9.48; Cl, 19.62; N, 15.51; O, 8.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

76990-56-2 (free base) 76990-85-7 (HCl)

Synonym

Milacemide HCl; Milacemide HCl salt; Milacemide Hydrochloride; Milacemide Hydrochloride salt; CP-1552S; SC-45864; SC 45864; SC45864; CP 1552S; CP1552S;

IUPAC/Chemical Name

2-(Pentylamino)acetamide hydrochloride

InChi Key

DNSCECUSJKDSKP-UHFFFAOYSA-N

InChi Code

InChI=1S/C7H16N2O.ClH/c1-2-3-4-5-9-6-7(8)10;/h9H,2-6H2,1H3,(H2,8,10);1H

SMILES Code

O=C(N)CNCCCCC.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM	comments
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 180.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liljequist R. Glycine modulates N-methyl-D-aspartic acid induced learning facilitation in rats. Amino Acids. 1996 Dec;10(4):345-58. doi: 10.1007/BF00805862. PubMed PMID: 24178595. 2: Finkelstein JE, Hengemihle JM, Ingram DK, Petri HL. Milacemide treatment in mice enhances acquisition of a Morris-type water maze task. Pharmacol Biochem Behav. 1994 Nov;49(3):707-10. PubMed PMID: 7862727. 3: Tonkiss J, Rawlins JN. The competitive NMDA antagonist AP5, but not the non-competitive antagonist MK801, induces a delay-related impairment in spatial working memory in rats. Exp Brain Res. 1991;85(2):349-58. PubMed PMID: 1680067. 4: Janssens de Varebeke P, Pauwels G, Buyse C, David-Remacle M, De Mey J, Roba J, Youdim MB. The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B. J Neurochem. 1989 Oct;53(4):1109-16. PubMed PMID: 2769256. 5: Van den Bosch de Aguilar P, Goemaere-Vanneste J. [Labeling cerebral activity with 3H-deoxyglucose after milacemide administration in the rat]. Acta Neurol Belg. 1984 Jan-Feb;84(1):21-5. French. PubMed PMID: 6720246.