MedKoo Cat#: 413287 | Name: Desoxycorticosterone pivalate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desoxycorticosterone pivalate sold under the brand names Zycortal, Percorten V, and Percorten M, is a mineralocorticoid medication and a mineralocorticoid ester.

Chemical Structure

Desoxycorticosterone pivalate
Desoxycorticosterone pivalate
CAS#808-48-0 (pivalate)

Theoretical Analysis

MedKoo Cat#: 413287

Name: Desoxycorticosterone pivalate

CAS#: 808-48-0 (pivalate)

Chemical Formula: C26H38O4

Exact Mass: 414.2770

Molecular Weight: 414.59

Elemental Analysis: C, 75.32; H, 9.24; O, 15.44

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
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Synonym
Desoxycorticosterone pivalate; Percorten pivalate; Zycortal; Percorten V; Percorten M; DOCP; Deoxycortone pivalate; DTMA; NSC95278; NSC-95278; NSC 95278
IUPAC/Chemical Name
2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pivalate
InChi Key
VVOIQBFMTVCINR-WWMZEODYSA-N
InChi Code
InChI=1S/C26H38O4/c1-24(2,3)23(29)30-15-22(28)21-9-8-19-18-7-6-16-14-17(27)10-12-25(16,4)20(18)11-13-26(19,21)5/h14,18-21H,6-13,15H2,1-5H3/t18-,19-,20-,21+,25-,26-/m0/s1
SMILES Code
CC(C)(C(OCC([C@H]1CC[C@H]2[C@@H]3CCC4=CC(CC[C@@]4([C@H]3CC[C@]12C)C)=O)=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 414.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sieber-Ruckstuhl NS, Reusch CE, Hofer-Inteeworn N, Kuemmerle-Fraune C, Müller C, Hofmann-Lehmann R, Boretti FS. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. J Vet Intern Med. 2019 May;33(3):1266-1271. doi: 10.1111/jvim.15475. Epub 2019 Mar 13. PMID: 30865322; PMCID: PMC6524388. 2: Lathan P, Thompson AL. Management of hypoadrenocorticism (Addison's disease) in dogs. Vet Med (Auckl). 2018 Feb 9;9:1-10. doi: 10.2147/VMRR.S125617. PMID: 30050862; PMCID: PMC6055912. 3: Deng Y, Xie M, Li Q, Xu X, Ou W, Zhang Y, Xiao H, Yu H, Zheng Y, Liang Y, Jiang C, Chen G, Du D, Zheng W, Wang S, Gong M, Chen Y, Tian R, Li T. Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF. Circ Res. 2021 Jan 22;128(2):232-245. doi: 10.1161/CIRCRESAHA.120.317933. Epub 2020 Nov 12. PMID: 33176578. 4: Jaffey JA, Nurre P, Cannon AB, DeClue AE. Desoxycorticosterone Pivalate Duration of Action and Individualized Dosing Intervals in Dogs with Primary Hypoadrenocorticism. J Vet Intern Med. 2017 Nov;31(6):1649-1657. doi: 10.1111/jvim.14828. Epub 2017 Sep 11. PMID: 28892205; PMCID: PMC5697171. 5: Münch L, Münch M, Paul H, Miklis A, Heinrich M, Neiger R. Therapie des primären Hypoadrenokortizismus beim Hund mit niedrig dosiertem Desoxycorticosteronpivalat [Therapy of primary hypoadrenocorticism in dogs with low dose desoxycorticosterone pivalate]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2020 Jun;48(3):171-175. German. doi: 10.1055/a-1166-8800. Epub 2020 Jun 18. PMID: 32557492. 6: Solocinski K, Holzworth M, Wen X, Cheng KY, Lynch IJ, Cain BD, Wingo CS, Gumz ML. Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice. Acta Physiol (Oxf). 2017 May;220(1):72-82. doi: 10.1111/apha.12804. Epub 2016 Oct 3. PMID: 27636900; PMCID: PMC5354999. 7: Oblak ML, Bacon NJ, Covey JL. Perioperative Management and Outcome of Bilateral Adrenalectomy in 9 Dogs. Vet Surg. 2016 Aug;45(6):790-7. doi: 10.1111/vsu.12514. Epub 2016 Jul 11. PMID: 27398811. 8: Bates JA, Shott S, Schall WD. Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism. Aust Vet J. 2013 Mar;91(3):77-82; discussion 81-2. doi: 10.1111/avj.12019. PMID: 23438457. 9: McCabe MD, Feldman EC, Lynn RC, Kass PH. Subcutaneous administration of desoxycorticosterone pivalate for the treatment of canine hypoadrenocorticism. J Am Anim Hosp Assoc. 1995 Mar-Apr;31(2):151-5. doi: 10.5326/15473317-31-2-151. PMID: 7773761. 10: Van Zyl M, Hyman WB. Desoxycorticosterone pivalate in the management of canine primary hypoadrenocorticism. J S Afr Vet Assoc. 1994 Sep;65(3):125-9. PMID: 7595920.