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MedKoo Cat#: 561636 | Name: Deoxycorticosterone Acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Deoxycorticosterone Acetate is the 21-acetate derivative of desoxycorticosterone, and has the potential for mineralocorticoid activity.

Chemical Structure

Deoxycorticosterone Acetate
Deoxycorticosterone Acetate
CAS#56-47-3 (acetate)

Theoretical Analysis

MedKoo Cat#: 561636

Name: Deoxycorticosterone Acetate

CAS#: 56-47-3 (acetate)

Chemical Formula: C23H32O4

Exact Mass: 372.2301

Molecular Weight: 372.50

Elemental Analysis: C, 74.16; H, 8.66; O, 17.18

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 650.00 2 Weeks
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Related CAS #
808-48-0 (pivalate) 56-47-3 (acetate)
Synonym
Deoxycorticosterone Acetate; DOCA; Percotol; Cortexone acetate; Desoxycortone acetate;
IUPAC/Chemical Name
[2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
InChi Key
VPGRYOFKCNULNK-ACXQXYJUSA-N
InChi Code
InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
SMILES Code
CC(OCC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 372.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiol Genomics. 2017 Dec 1;49(12):722-732. doi: 10.1152/physiolgenomics.00087.2017. Epub 2017 Oct 6. Review. PubMed PMID: 28986397. 2: Basting T, Lazartigues E. DOCA-Salt Hypertension: an Update. Curr Hypertens Rep. 2017 Apr;19(4):32. doi: 10.1007/s11906-017-0731-4. Review. PubMed PMID: 28353076. 3: Auchus RJ. Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic. J Steroid Biochem Mol Biol. 2017 Jan;165(Pt A):71-78. doi: 10.1016/j.jsbmb.2016.02.002. Epub 2016 Feb 6. Review. PubMed PMID: 26862015; PubMed Central PMCID: PMC4976049. 4: Maayah ZH, El-Kadi AO. The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy. Arch Toxicol. 2016 Jan;90(1):119-36. doi: 10.1007/s00204-015-1620-8. Epub 2015 Nov 2. Review. PubMed PMID: 26525395. 5: Ndisang JF. Role of the heme oxygenase-adiponectin-atrial natriuretic peptide axis in renal function. Curr Pharm Des. 2015;21(30):4380-91. Review. PubMed PMID: 26234796. 6: McMaster WG, Kirabo A, Madhur MS, Harrison DG. Inflammation, immunity, and hypertensive end-organ damage. Circ Res. 2015 Mar 13;116(6):1022-33. doi: 10.1161/CIRCRESAHA.116.303697. Review. PubMed PMID: 25767287; PubMed Central PMCID: PMC4535695. 7: Franco M, Bautista-Pérez R, Pérez-Méndez O. Purinergic receptors in tubulointerstitial inflammatory cells: a pathophysiological mechanism of salt-sensitive hypertension. Acta Physiol (Oxf). 2015 May;214(1):75-87. doi: 10.1111/apha.12471. Epub 2015 Feb 28. Review. PubMed PMID: 25683649. 8: Lee LK, Kim MY, Kim JH, Lee JU, Park BS, Yang SM, Jeon HJ, Lee WD, Noh JW, Kwak TY, Lee TH, Kim JY, Kim HY, Hwang BY, Kim B, Kim J. A review of deoxycorticosterone acetate-salt hypertension and its relevance for cardiovascular physiotherapy research. J Phys Ther Sci. 2015 Jan;27(1):303-7. doi: 10.1589/jpts.27.303. Epub 2015 Jan 9. Review. PubMed PMID: 25642096; PubMed Central PMCID: PMC4305587. 9: Ayari H. [Respective roles of cortisol, aldosterone and angiotensin II during pathophysiology of atherosclerosis]. Ann Biol Clin (Paris). 2013 Jul-Aug;71(4):381-8. doi: 10.1684/abc.2013.0868. Review. French. PubMed PMID: 23906564. 10: Elshenawy OH, Anwar-Mohamed A, El-Kadi AO. 20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases. Curr Drug Metab. 2013 Jul;14(6):706-19. Review. PubMed PMID: 23701160. 11: Ohkita M, Kiso Y, Matsumura Y. Pharmacology in health foods: improvement of vascular endothelial function by French maritime pine bark extract (Flavangenol). J Pharmacol Sci. 2011;115(4):461-5. Epub 2011 Mar 24. Review. PubMed PMID: 21436602. 12: Agarwal N, Hutson TE, Vogelzang NJ, Sonpavde G. Abiraterone acetate: a promising drug for the treatment of castration-resistant prostate cancer. Future Oncol. 2010 May;6(5):665-79. doi: 10.2217/fon.10.48. Review. Erratum in: Future Oncol. 2011 May;7(5):695-6. PubMed PMID: 20465382. 13: Yemane H, Busauskas M, Burris SK, Knuepfer MM. Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)-salt hypertension in rats. Exp Physiol. 2010 Jan;95(1):51-5. doi: 10.1113/expphysiol.2008.046334. Epub 2009 Aug 21. Review. PubMed PMID: 19700514. 14: Ramage AG, Villalón CM. 5-hydroxytryptamine and cardiovascular regulation. Trends Pharmacol Sci. 2008 Sep;29(9):472-81. Review. PubMed PMID: 19086344. 15: Abrams JM, Osborn JW. A role for benzamil-sensitive proteins of the central nervous system in the pathogenesis of salt-dependent hypertension. Clin Exp Pharmacol Physiol. 2008 May;35(5-6):687-94. doi: 10.1111/j.1440-1681.2008.04929.x. Review. PubMed PMID: 18387084; PubMed Central PMCID: PMC2693203. 16: Bae YM, Sung DJ, Noh HJ, Kim J, Park SW, Kim B, Cho SI. Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats. J Smooth Muscle Res. 2007 Jun;43(3):85-97. Review. PubMed PMID: 17721045. 17: Feldstein C, Romero C. Role of endothelins in hypertension. Am J Ther. 2007 Mar-Apr;14(2):147-53. Review. PubMed PMID: 17414582. 18: Perez del Villar C, Garcia Alonso CJ, Feldstein CA, Juncos LA, Romero JC. Role of endothelin in the pathogenesis of hypertension. Mayo Clin Proc. 2005 Jan;80(1):84-96. Review. PubMed PMID: 15667034. 19: Takaoka M, Ohkita M, Matsumura Y. Pathophysiological role of proteasome-dependent proteolytic pathway in endothelin-1-related cardiovascular diseases. Curr Vasc Pharmacol. 2003 Mar;1(1):19-26. Review. PubMed PMID: 15320849. 20: Agarwal R, Campbell RC, Warnock DG. Oxidative stress in hypertension and chronic kidney disease: role of angiotensin II. Semin Nephrol. 2004 Mar;24(2):101-14. Review. PubMed PMID: 15017522.