Synonym
Heptaminol Free Base; Corasore; Heptaminolum
IUPAC/Chemical Name
6-amino-2-methylheptan-2-ol
InChi Key
LREQLEBVOXIEOM-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H19NO/c1-7(9)5-4-6-8(2,3)10/h7,10H,4-6,9H2,1-3H3
SMILES Code
CC(CCCC(C)(O)C)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
145.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dib J, Bosse C, Tsivou M, Glatt AM, Geisendorfer T, Geyer H, Gmeiner G, Sigmund G, Thevis M. Is heptaminol a (major) metabolite of octodrine? Drug Test Anal. 2019 Nov;11(11-12):1761-1763. doi: 10.1002/dta.2737. Epub 2019 Dec 11. PMID: 31763761.
2: Omar MA, Nagy DM, Halim ME. Fluorescamine-based fluorophore for spectrofluorimetric determination of heptaminol in human plasma; application to spiked human plasma. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Feb 15;227:117711. doi: 10.1016/j.saa.2019.117711. Epub 2019 Oct 25. PMID: 31690484.
3: Halim ME, Omar MA, Nagy DM. Condensation of heptaminol hydrochloride for its spectrofluorimetric determination in pure form and tablets: application in human plasma. Luminescence. 2020 Sep;35(6):821-826. doi: 10.1002/bio.3787. Epub 2020 Jan 28. PMID: 31994292.
4: Omar MA, Nagy DM, Halim ME. Utility of ninhydrin reagent for spectrofluorimetric determination of heptaminol in human plasma. Luminescence. 2018 Sep;33(6):1107-1112. doi: 10.1002/bio.3516. Epub 2018 Jul 3. PMID: 29968975.
5: Grobecker H, Grobecker H. Untersuchungen zum Wirkungsmechanismus von Heptaminol [On the mode of action of heptaminol (author's transl)]. Arzneimittelforschung. 1976;26(12):2167-71. German. PMID: 1037266.
6: Bahloul M, Chaari A, Ben Mbarek MN, Kallel H, Bouaziz M. Use of heptaminol hydrochloride for catecholamine weaning in septic shock. Am J Ther. 2012 Jan;19(1):e8-17. doi: 10.1097/MJT.0b013e3181e9b630. PMID: 20720484.
7: Tseng YL, Liu CH, Kuo FH, Shieh MH. Solid-phase column chromatographic and gas chromatographic-mass spectrometric determination of heptaminol in human urine and related pharmacokinetic profiles. J Anal Toxicol. 2006 Jul- Aug;30(6):365-9. doi: 10.1093/jat/30.6.365. PMID: 16872566.
8: Drugs for hypotension: disproportionate harms with etilefrine and heptaminol. . Prescrire Int. 2015 Jul;24(162):184. PMID: 26240886.
9: Pourrias B. Le chlorhydrate d'heptaminol: nouvelles données [Heptaminol chlorhydrate: new data]. Ann Pharm Fr. 1991;49(3):127-38. French. PMID: 1929117.
10: Fontas B, Mambrini J. Heptaminol-chlorohydrate agit sur un épithélium transporteur [Heptaminol hydrochloride as an epithelium transporter]. Can J Physiol Pharmacol. 1990 Jul;68(7):791-9. French. PMID: 2383795.
