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MedKoo Cat#: 413235 | Name: Colistin nonapeptide HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Colistin nonapeptide HCl is the salt form of Colistin nonapeptide, which binds to LPS and possesses antiendotoxin activity

Chemical Structure

Colistin nonapeptide HCl
Colistin nonapeptide HCl
CAS#52396-32-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 413235

Name: Colistin nonapeptide HCl

CAS#: 52396-32-4 (HCl)

Chemical Formula: C40H77ClN14O11

Exact Mass:

Molecular Weight: 965.59

Elemental Analysis: C, 49.76; H, 8.04; Cl, 3.67; N, 20.31; O, 18.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
32530-94-2 (free base) 52396-32-4 (HCl)
Synonym
Colistin nonapeptide HCl; 1-De(N(sup 2)-(6-methyl-1-oxooctyl)-L-2,4-diaminobutanoic acid)polymyxin E1 hydrochloride
IUPAC/Chemical Name
2-amino-N-(4-amino-1-oxo-1-((6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide hydrochloride
InChi Key
IDTSHEDVGPKYSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C40H76N14O11.ClH/c1-19(2)17-28-37(62)49-23(7-12-41)32(57)48-26(10-15-44)36(61)54-31(22(6)56)40(65)46-16-11-27(50-33(58)25(9-14-43)51-39(64)30(45)21(5)55)35(60)47-24(8-13-42)34(59)52-29(18-20(3)4)38(63)53-28;/h19-31,55-56H,7-18,41-45H2,1-6H3,(H,46,65)(H,47,60)(H,48,57)(H,49,62)(H,50,58)(H,51,64)(H,52,59)(H,53,63)(H,54,61);1H
SMILES Code
CC(CC1NC(C(NC(C(NC(C(NC(C(NC(C(C(O)C)N)=O)CCN)=O)CCNC(C(C(O)C)NC(C(NC(C(NC1=O)CCN)=O)CCN)=O)=O)=O)CCN)=O)CC(C)C)=O)C.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 965.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Warren HS, Kania SA, Siber GR. Binding and neutralization of bacterial lipopolysaccharide by colistin nonapeptide. Antimicrob Agents Chemother. 1985 Jul;28(1):107-12. doi: 10.1128/aac.28.1.107. PMID: 2412488; PMCID: PMC176319. 2: Ito-Kagawa M, Koyama Y. Studies on the selectivity of action of colistin, colistin nonapeptide and colistin heptapeptide on the cell envelope of Escherichia coli. J Antibiot (Tokyo). 1984 Aug;37(8):926-8. doi: 10.7164/antibiotics.37.926. PMID: 6384168.