MedKoo Cat#: 413172 | Name: Clorprenaline free base
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clorprenaline is a β2-adrenergic receptor agonist. As a bronchodilator it has been used for the treatment of bronchial asthma, bronchitis and other respiratory diseases. It is a potential new lean meat-boosting feed additive because it can promote animal muscular mass growth and decrease fat accumulation.

Chemical Structure

 Clorprenaline free base
Clorprenaline free base
CAS#3811-25-4 (free base)

Theoretical Analysis

MedKoo Cat#: 413172

Name: Clorprenaline free base

CAS#: 3811-25-4 (free base)

Chemical Formula: C11H16ClNO

Exact Mass: 213.0920

Molecular Weight: 213.71

Elemental Analysis: C, 61.82; H, 7.55; Cl, 16.59; N, 6.55; O, 7.49

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
Clorprenaline; L20025; L-20025; L 20025; Isoprophenamine; E 241; E241; E-241; (±)-Chloroprenaline; Isoprofenamine
IUPAC/Chemical Name
o-Chloro-alpha-((isopropylamino)methyl)benzyl alcohol
InChi Key
SSMSBSWKLKKXGG-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16ClNO/c1-8(2)13-7-11(14)9-5-3-4-6-10(9)12/h3-6,8,11,13-14H,7H2,1-2H3
SMILES Code
CC(NCC(O)C1=CC=CC=C1Cl)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 213.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bi Y, Wang Y, Ye N, Sun L, Wang H, Xu S, Xiao X. [Detection and identification of major metabolites of clorprenaline in swine urine using ultra- performance liquid chromatography-quadrupole time-of-flight mass spectrometry]. Se Pu. 2015 Jul;33(7):704-10. Chinese. doi: 10.3724/sp.j.1123.2015.03007. PMID: 26672198. 2: Peng T, Zhang FS, Yang WC, Li DX, Chen Y, Xiong YH, Wei H, Lai WH. Lateral- flow assay for rapid quantitative detection of clorprenaline residue in swine urine. J Food Prot. 2014 Oct;77(10):1824-9. doi: 10.4315/0362-028X.JFP-14-103. PMID: 25285506. 3: Wang B, Wang A, Xu C, Tong Z, Wang Y, Zhuo X, Fu L, Yao W, Wang J, Wu Y. Molecular, morphological and behavioral alterations of zebrafish (Danio rerio) embryos/larvae after clorprenaline hydrochloride exposure. Food Chem Toxicol. 2023 Jun;176:113776. doi: 10.1016/j.fct.2023.113776. Epub 2023 Apr 12. PMID: 37059383. 4: Shao X, Zhang J, Li D, Yue J, Chen Z. Preparation of Fe2O3-Clorprenaline/Tetraphenylborate Nanospheres and Their Application as Ion Selective Electrode for Determination of Clorprenaline in Pork. Nanoscale Res Lett. 2016 Dec;11(1):178. doi: 10.1186/s11671-016-1388-7. Epub 2016 Apr 5. PMID: 27044307; PMCID: PMC4820410. 5: Liang S, Yan H, Cao J, Han Y, Shen S, Bai L. Molecularly imprinted phloroglucinol-formaldehyde-melamine resin prepared in a deep eutectic solvent for selective recognition of clorprenaline and bambuterol in urine. Anal Chim Acta. 2017 Jan 25;951:68-77. doi: 10.1016/j.aca.2016.11.009. Epub 2016 Nov 11. PMID: 27998487. 6: Li QY, Zhuo ZL, Chen YW. [Simultaneous determination of three components in compound clorprenaline tablet by using the derivative-complementary tristimulus method]. Yao Xue Xue Bao. 1990;25(5):357-61. Chinese. PMID: 2284956. 7: Kraft B, Armstrong JG. Clinical studies with clorprenaline, a new bronchodilator with and without the antihistamine methapyrilene. Appl Ther. 1965 Oct;7(10):829-32. PMID: 4378597. 8: Goto Y, Takumi Y, Noguchi H, Aochi O. [Effects of inhalation of a bronchodilator, clorprenaline]. Masui. 1970 Jan;19(1):30-8. Japanese. PMID: 5460875. 9: Yan H, Liu S, Gao M, Sun N. Ionic liquids modified dummy molecularly imprinted microspheres as solid phase extraction materials for the determination of clenbuterol and clorprenaline in urine. J Chromatogr A. 2013 Jun 14;1294:10-6. doi: 10.1016/j.chroma.2013.04.024. Epub 2013 Apr 17. PMID: 23659982. 10: Gu XQ, Qian WX, Wang YJ, Teng CW. [Studies on sustained-release dosage forms for clorprenaline pamoate]. Yao Xue Xue Bao. 1982 Jun;17(6):469-71. Chinese. PMID: 7148472. 11: Igarashi T, Wakabayashi T, Shoji T, Tomiuga T. Die beta-sympathomimetische Wirkung von d- und 1-Clorprenalin an normalen und mit Reserpin behandelten Hunden [Beta-sympathomimetic effect of d- and 1-Clorprenaline in normal and reserpinized dogs]. Arzneimittelforschung. 1970 Nov;20(11):1738-41. German. PMID: 4395321. 12: Li Q, Wang J, Zheng YY, Yang L, Zhang Y, Bian L, Zheng J, Li Z, Zhao X, Zhang Y. Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilised β(2)-adrenoceptor. J Chromatogr A. 2015 Jul 3;1401:75-83. doi: 10.1016/j.chroma.2015.05.012. Epub 2015 May 14. PMID: 26002106. 13: Zhou L, Lun J, Liu Y, Jiang Z, Di X, Guo X. In situ immobilization of sulfated-β-cyclodextrin as stationary phase for capillary electrochromatography enantioseparation. Talanta. 2019 Aug 1;200:1-8. doi: 10.1016/j.talanta.2019.03.034. Epub 2019 Mar 6. PMID: 31036161. 14: Deng M, Xue M, Liu Y, Zhao M. Preparation of a novel hydroxypropyl-γ- cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography. Chirality. 2021 May;33(5):188-195. doi: 10.1002/chir.23300. Epub 2021 Feb 18. PMID: 33604997. 15: Zhou L, Qi YG, Zhang G, Xu YY, Feng H. [2-(2-Chloro-phen-yl)-2-hy-droxy-eth- yl](isoprop-yl)ammonium 4-hy-droxy-benzoate. Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 18;67(Pt 1):o192. doi: 10.1107/S1600536810051536. PMID: 21522694; PMCID: PMC3050334. 16: Liang Q, Shi B, Yao Q, Wang T, Ji X, Zhang Y, Wang J, Zhao X. Early potential evaluation of lead compounds from a DNA-encoded library by the determination of their thermodynamics through a chromatographic method based on immobilized β2-adrenoceptor. Bioorg Med Chem. 2022 Aug 15;68:116864. doi: 10.1016/j.bmc.2022.116864. Epub 2022 May 31. PMID: 35671625. 17: Gao J, Chang Z, Tian R, Li P, Ahmad F, Jia X, Liang Q, Zhao X. Reversible and site-specific immobilization of β2-adrenergic receptor by aptamer-directed method for receptor-drug interaction analysis. J Chromatogr A. 2020 Jul 5;1622:461091. doi: 10.1016/j.chroma.2020.461091. Epub 2020 Apr 28. PMID: 32376022. 18: Zeng K, Wang J, Sun Z, Li Q, Liao S, Zhao X, Zheng X. Rapid analysis of interaction between six drugs and β2 -adrenergic receptor by injection amount-dependent method. Biomed Chromatogr. 2017 Jun;31(6). doi: 10.1002/bmc.3897. Epub 2017 Jan 10. PMID: 27859454. 19: Zhong Y, Hou C, Gao X, Wang M, Yao Y, Chen M, Di B, Su M. Application of wastewater-based epidemiology to estimate the usage of beta-agonists in 31 cities in China. Sci Total Environ. 2023 Oct 10;894:164956. doi: 10.1016/j.scitotenv.2023.164956. Epub 2023 Jun 19. PMID: 37343858. 20: Wang L, He L, Wang Z, Wang X, Shu J, Yang J, Zhang G, Zeng Z. Selection of a representative matrix for the multiresidue analysis of nine β-agonists in animal tissues and urine with LC-MS/MS. Analyst. 2013 Aug 21;138(16):4579-84. doi: 10.1039/c3an36806h. Epub 2013 Jun 10. PMID: 23749061.