Isotretinoin anisatil | CAS# 127471-94-7 | Vitamin A derivative

MedKoo Cat#: 575965 | Name: Isotretinoin anisatil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isotretinoin anisatilis an orally active retinoic acid derivative for the treatment of severe refractory nodulocystic acne. It acts primarily by reducing sebaceous gland size and sebum production, and as a result alters skin surface lipid composition.

Chemical Structure

Isotretinoin anisatil

CAS#127471-94-7

Theoretical Analysis

MedKoo Cat#: 575965

Name: Isotretinoin anisatil

CAS#: 127471-94-7

Chemical Formula: C29H36O4

Exact Mass: 448.2614

Molecular Weight: 448.60

Elemental Analysis: C, 77.65; H, 8.09; O, 14.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GR 116526X; GR116526X; GR-116526X; Hydroxyanasatil retinoate; Isotretinoin anisatil; MDI 403; MDI403; MDI-403

IUPAC/Chemical Name

2-(4-methoxyphenyl)-2-oxoethyl (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate

InChi Key

YDBCQZCJDPGBBE-BVYOMHTDSA-N

InChi Code

InChI=1S/C29H36O4/c1-21(12-17-26-23(3)11-8-18-29(26,4)5)9-7-10-22(2)19-28(31)33-20-27(30)24-13-15-25(32-6)16-14-24/h7,9-10,12-17,19H,8,11,18,20H2,1-6H3/b10-7+,17-12+,21-9+,22-19-

SMILES Code

COc1ccc(cc1)C(=O)COC(=O)\C=C(\C)/C=C/C=C(\C)/C=C/C2=C(C)CCCC2(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 448.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Khalil NY, Darwish IA, Al-Qahtani AA. Isotretinoin. Profiles Drug Subst Excip Relat Methodol. 2020;45:119-157. doi: 10.1016/bs.podrm.2019.10.005. Epub 2019 Dec 6. PMID: 32164966. 2. Huang YC, Cheng YC. Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis. J Am Acad Dermatol. 2017 Jun;76(6):1068-1076.e9. doi: 10.1016/j.jaad.2016.12.028. Epub 2017 Mar 11. Erratum in: J Am Acad Dermatol. 2017 Nov 14;: PMID: 28291553. 3. Tan TH, Hallett R, Yesudian PD. Efficacy and relapse rates of different Isotretinoin dosages in treating acne vulgaris: systemic review. Clin Med (Lond). 2016 Jun 1;16 Suppl 3(Suppl 3):s34. doi: 10.7861/clinmedicine.16-3-s34. PMID: 27252338; PMCID: PMC4989953.