MedKoo Cat#: 575935 | Name: GOE-5438

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GOE-5438 is a calcium antagonist that has been shown to inhibit the excitation and contraction of single cardiomyocytes.

Chemical Structure

GOE-5438
GOE-5438
CAS#103183-79-5

Theoretical Analysis

MedKoo Cat#: 575935

Name: GOE-5438

CAS#: 103183-79-5

Chemical Formula: C22H23F3N2O3

Exact Mass: 420.1661

Molecular Weight: 420.43

Elemental Analysis: C, 62.85; H, 5.51; F, 13.56; N, 6.66; O, 11.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GOE-5438; GOE5438; GOE 5438
IUPAC/Chemical Name
1,6-Naphthyridine-3-carboxylic acid, 1,4-dihydro-2-methyl-5-(1-methylethoxy)-4-(2-(trifluoromethyl)phenyl)-, ethyl ester, (+-)-
InChi Key
XVXQOAYCEUDQTQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23F3N2O3/c1-5-29-21(28)17-13(4)27-16-10-11-26-20(30-12(2)3)19(16)18(17)14-8-6-7-9-15(14)22(23,24)25/h6-12,18,27H,5H2,1-4H3
SMILES Code
CCOC(=O)C1=C(C)Nc2ccnc(OC(C)C)c2C1c3ccccc3C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Koidl B, Wagner B, Tritthart HA. The inhibitory effects of the novel calcium antagonist Goe 5438 on calcium-dependent processes of excitation and contraction of single cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):447-53. doi: 10.1007/BF00169538. PMID: 3405319. 2. Pucilowski O, Rezvani AH, Janowsky DS. Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438. Psychopharmacology (Berl). 1992;107(2-3):447-52. doi: 10.1007/BF02245174. PMID: 1615142.