DN401 is a potent and selective TRAP1 Inhibitor with IC50 = 79 nM for TRAP1, and 698 nM for Hsp90. DN401 exhibited potent anticancer activity. DN401 exhibited cytotoxic activity that was superior to Hsp90 inhibitors in several human cancer cells. DN401 has superior cancer-specific cytotoxicity but reduced cytotoxic effects in normal cells compared with those of other Hsp90 inhibitors.
MedKoo Cat#: 407801
Name: DN401
CAS#: 2135749-60-7
Chemical Formula: C13H9BrClN5O2
Exact Mass: 380.9628
Molecular Weight: 382.60
Elemental Analysis: C, 40.81; H, 2.37; Br, 20.88; Cl, 9.27; N, 18.30; O, 8.36
The following data is based on the product molecular weight 382.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
