Mdl 28815 | CAS#104905-12-6

MedKoo Cat#: 535029 | Name: Mdl 28815

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mdl 28815 is a potent inhibitor of 2,3-oxidosqualene cycloartenol & lanosterol cyclases.

Chemical Structure

Mdl 28815

CAS#104905-12-6

Theoretical Analysis

MedKoo Cat#: 535029

Name: Mdl 28815

CAS#: 104905-12-6

Chemical Formula: C24H47NO

Exact Mass: 365.3658

Molecular Weight: 365.65

Elemental Analysis: C, 78.84; H, 12.96; N, 3.83; O, 4.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Mdl 28815; Mdl-28815; Mdl28815

IUPAC/Chemical Name

6-Isoquinolinol, decahydro-5,8a-dimethyl-2-(1,5,9-trimethyldecyl)-

InChi Key

YSACNAXEZHCMEQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H47NO/c1-18(2)9-7-10-19(3)11-8-12-20(4)25-16-14-22-21(5)23(26)13-15-24(22,6)17-25/h18-23,26H,7-17H2,1-6H3

SMILES Code

OC1C(C)C2CCN(C(C)CCCC(C)CCCC(C)C)CC2(C)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 365.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Van Sickle WA, Wilson PK, Wannamaker MW, Cooper JR, Flanagan MA, McCarthy JR, Bey P, Jackson RL. An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815). J Pharmacol Exp Ther. 1993 Dec;267(3):1243-9. PMID: 8263786. 2: Gerst N, Duriatti A, Schuber F, Taton M, Benveniste P, Rahier A. Potent inhibition of cholesterol biosynthesis in 3T3 fibroblasts by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol, a new 2,3-oxidosqualene cyclase inhibitor. Biochem Pharmacol. 1988 May 15;37(10):1955-64. doi: 10.1016/0006-2952(88)90542-4. PMID: 3377803. 3: Moebius FF, Reiter RJ, Hanner M, Glossmann H. High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase. Br J Pharmacol. 1997 May;121(1):1-6. doi: 10.1038/sj.bjp.0701079. PMID: 9146879; PMCID: PMC1564641. 4: Taton M, Benveniste P, Rahier A. N-[(1,5,9)-trimethyl-decyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases. Biochem Biophys Res Commun. 1986 Jul 31;138(2):764-70. doi: 10.1016/s0006-291x(86)80562-9. PMID: 3741433.