IUPAC/Chemical Name
Benzamide, N-(((4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)amino)carbonyl)-2,6-difluoro-
InChi Key
RYLHNOVXKPXDIP-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H11ClF6N2O3/c22-12-8-10(21(26,27)28)4-7-17(12)33-11-5-6-16(15(25)9-11)29-20(32)30-19(31)18-13(23)2-1-3-14(18)24/h1-9H,(H2,29,30,31,32)
SMILES Code
O=C(NC(NC1=CC=C(OC2=CC=C(C(F)(F)F)C=C2Cl)C=C1F)=O)C3=C(F)C=CC=C3F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
488.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Park S, Lee JY, Park H, Song G, Lim W. Toxic effects of flufenoxuron on development and vascular formation during zebrafish embryogenesis. Aquat Toxicol. 2019 Nov;216:105307. doi: 10.1016/j.aquatox.2019.105307. Epub 2019 Sep 18. PMID: 31557631.
2: Chang J, Li W, Xu P, Guo B, Wang H. Dose-dependent effects of flufenoxuron on thyroid system of mature female lizards (Eremias argus) and their offspring. Sci Total Environ. 2019 Mar 1;654:714-719. doi: 10.1016/j.scitotenv.2018.11.167. Epub 2018 Nov 12. PMID: 30448662.
3: Chang J, Li W, Guo B, Xu P, Wang Y, Li J, Wang H. Unraveling the different toxic effect of flufenoxuron on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages. Chemosphere. 2017 Apr;172:210-216. doi: 10.1016/j.chemosphere.2017.01.002. Epub 2017 Jan 4. PMID: 28073034.
4: Bae H, You S, Lim W, Song G. Flufenoxuron disturbs early pregnancy in pigs via induction of cell death with ER-mitochondrial dysfunction. J Hazard Mater. 2020 May 24;401:122996. doi: 10.1016/j.jhazmat.2020.122996. Epub ahead of print. PMID: 32763671.
5: Arakawa T, Furuta Y, Miyazawa M, Kato M. Flufenoxuron, an insect growth regulator, promotes peroral infection by nucleopolyhedrovirus (BmNPV) budded particles in the silkworm, Bombyx mori L. J Virol Methods. 2002 Feb;100(1-2):141-7. doi: 10.1016/s0166-0934(01)00414-1. PMID: 11742661.
6: Rhee J, Cho B, Lee J, Moon S, Yum H. Liquid chromatography with tandem mass spectrometry for the determination of flufenoxuron in blood using automatic solid phase extraction and its application to a fatal case of flufenoxuron poisoning. Forensic Sci Int. 2015 Dec;257:49-53. doi: 10.1016/j.forsciint.2015.07.041. Epub 2015 Jul 31. PMID: 26282510.
7: Woo JH, Lim YS. Severe human poisoning with a flufenoxuron-containing insecticide: Report of a case with transient myocardial dysfunction and review of the literature. Clin Toxicol (Phila). 2015 Jul;53(6):569-72. doi: 10.3109/15563650.2015.1040158. Epub 2015 May 7. PMID: 25948501.
8: Brites-Neto J, Brasil J, de Andrade J, Saqui GL. Evaluation of an association of alpha-cypermethrin and flufenoxuron for tick control in an area at risk of Brazilian spotted fever. Vet Parasitol. 2017 Apr 30;238:1-4. doi: 10.1016/j.vetpar.2017.03.002. Epub 2017 Mar 27. PMID: 28377149.
9: Hernández MM, Martínez-Villar E, Peace C, Pérez-Moreno I, Marco V. Compatibility of the entomopathogenic fungus Beauveria bassiana with flufenoxuron and azadirachtin against Tetranychus urticae. Exp Appl Acarol. 2012 Dec;58(4):395-405. doi: 10.1007/s10493-012-9594-1. Epub 2012 Jun 29. PMID: 22744196.
10: Jeong J, Yeom S, Ryu J, Han SK, Cho SJ, Kim J. A case of human poisoning with a flufenoxuron-containing insecticide. Clin Toxicol (Phila). 2010 Jan;48(1):87-9. doi: 10.3109/15563650903409781. PMID: 20070176.