MedKoo Cat#: 413130 | Name: Chlormidazole free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlormidazole is an antifungal agent. It belongs to the imidazole class of antifungal drugs, which are known for their broad-spectrum activity against various fungal infections. Chlormidazole works by inhibiting the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption compromises the integrity of the fungal cell membrane, leading to leakage of intracellular contents and eventual cell death.

Chemical Structure

Chlormidazole free base
CAS#3689-76-7 (free base)

Theoretical Analysis

MedKoo Cat#: 413130

Name: Chlormidazole free base

CAS#: 3689-76-7 (free base)

Chemical Formula: C15H13ClN2

Exact Mass: 256.0767

Molecular Weight: 256.73

Elemental Analysis: C, 70.18; H, 5.10; Cl, 13.81; N, 10.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
3689-76-7 (free base) 74298-63-8 (HCl) 760115-45-5 (free base) 54118-67-1(HCl)
Synonym
Chlormidazole (free base); H-115; H115; H 115
IUPAC/Chemical Name
1-p-Chlorobenzyl-2-methylbenzimidazole
InChi Key
WNAQOLSMVPFGTE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13ClN2/c1-11-17-14-4-2-3-5-15(14)18(11)10-12-6-8-13(16)9-7-12/h2-9H,10H2,1H3
SMILES Code
CC1=NC2=CC=CC=C2N1CC3=CC=C(Cl)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 256.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Musiol R, Kowalczyk W. Azole antimycotics--a highway to new drugs or a dead end? Curr Med Chem. 2012;19(9):1378-88. doi: 10.2174/092986712799462621. PMID: 22257053. 2: Krasiejko I, Gajewicz L, Lipnicki D. Oznaczanie wrazliwości bakterii tlenowych i drozdzaków z rodzaju Candida na chlorowodorek chlormidazolu in vitro [Sensitivity of aerobic bacteria and Candida species to chlormidazole hydrochloride in vitro]. Pol Tyg Lek. 1990 Jan 22-29;45(4-5):91-2. Polish. PMID: 2395759. 3: Holt RJ. Topical pharmacology of imidazole antifungals. J Cutan Pathol. 1976;3(1):45-59. doi: 10.1111/j.1600-0560.1976.tb00846.x. PMID: 945306. 4: Corelli F, Massa S, Stefancich G, Artico M, Panico S, Simonetti N. Ricerche su composti antibatterici ed antifungini. Nota V-Sintesi ed attività antimicrobica di N-(2-ariletilaminofenil)-1H-pirril-1-amine e di 1-(1H-pirrol-1-il)-2-arilmetilbenzimidazoli [Antibacterial and antifungal compounds. V. Synthesis and antimicrobial activity of N-(2-arylethylaminophenyl)-1H-pyrryl-1-amine and 1-(1H-pyrrol-1-yl)-2-arylmethylbenzimidazole)]. Farmaco Sci. 1985 Jul;40(7):501-8. Italian. PMID: 4043374.