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MedKoo Cat#: 413125 | Name: Clofilium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofilium (free base) is an antiarrhythmic agent

Chemical Structure

Clofilium
Clofilium
CAS# 68379-02-2 (cation)

Theoretical Analysis

MedKoo Cat#: 413125

Name: Clofilium

CAS#: 68379-02-2 (cation)

Chemical Formula: C21H37ClN+

Exact Mass: 338.2609

Molecular Weight: 338.98

Elemental Analysis: C, 74.41; H, 11.00; Cl, 10.46; N, 4.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
68379-02-2 (cation) 92953-10-1 (Tosylate) 68379-03-3 (Phosphate)
Synonym
Clofilium; Clofilium ion; Clofilium cation; UNII-847G178BMC;
IUPAC/Chemical Name
Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-
InChi Key
WPSYTTKBGAZSCX-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H37ClN/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20/h14-17H,4-13,18-19H2,1-3H3/q+1
SMILES Code
CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(Cl)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abi Nahed R, Martinez G, Hograindleur JP, Le Blévec E, Camugli S, Le Boucher R, Ray PF, Escoffier J, Schmitt E, Arnoult C. Slo3 K+ channel blocker clofilium extends bull and mouse sperm-fertilizing competence. Reproduction. 2018 Dec 1;156(6):463-476. doi: 10.1530/REP-18-0075. PMID: 30422808. 2: Choi BY, Kim HY, Lee KH, Cho YH, Kong G. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147(1-2):85-93. doi: 10.1016/s0304-3835(99)00280-3. PMID: 10660093. 3: Friedrichs GS, Chi L, Green AL, Lucchesi BR. Antifibrillatory effects of clofilium in the rabbit isolated heart. Br J Pharmacol. 1994 Sep;113(1):209-15. doi: 10.1111/j.1476-5381.1994.tb16195.x. PMID: 7812612; PMCID: PMC1510047. 4: de Los Angeles Tejada M, Stolpe K, Meinild AK, Klaerke DA. Clofilium inhibits Slick and Slack potassium channels. Biologics. 2012;6:465-70. doi: 10.2147/BTT.S33827. Epub 2012 Dec 12. PMID: 23271893; PMCID: PMC3526865. 5: Malayev AA, Nelson DJ, Philipson LH. Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. Mol Pharmacol. 1995 Jan;47(1):198-205. PMID: 7838129. 6: Facchinello N, Laquatra C, Locatello L, Beffagna G, Brañas Casas R, Fornetto C, Dinarello A, Martorano L, Vettori A, Risato G, Celeghin R, Meneghetti G, Santoro MM, Delahodde A, Vanzi F, Rasola A, Dalla Valle L, Rasotto MB, Lodi T, Baruffini E, Argenton F, Tiso N. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death Dis. 2021 Jan 19;12(1):100. doi: 10.1038/s41419-020-03359-z. PMID: 33469036; PMCID: PMC7815880. 7: Șterbuleac D, Maniu CL. Computer Simulations Reveal a Novel Blocking Mode of the hERG Ion Channel by the Antiarrhythmic Agent Clofilium. Mol Inform. 2018 Jul;37(6-7):e1700142. doi: 10.1002/minf.201700142. Epub 2018 Feb 21. PMID: 29465167. 8: Hasumi H, Matsuda R, Shimamoto K, Hata Y, Kaneko N. K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization. Eur J Pharmacol. 2007 Jan 19;555(1):54-60. doi: 10.1016/j.ejphar.2006.10.005. Epub 2006 Oct 17. PMID: 17112502. 9: Batey AJ, Coker SJ. Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. Br J Pharmacol. 2002 Feb;135(4):1003-12. doi: 10.1038/sj.bjp.0704550. PMID: 11861329; PMCID: PMC1573214. 10: Dorian P, Wang M, David I, Feindel C. Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model. Circulation. 1991 Feb;83(2):614-21. doi: 10.1161/01.cir.83.2.614. PMID: 1991379.