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MedKoo Cat#: 529000 | Name: Clofilium phosphate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofilium phosphate is an anti-arrhythmia agent.

Chemical Structure

Clofilium phosphate
Clofilium phosphate
CAS#68379-03-3 (Phosphate)

Theoretical Analysis

MedKoo Cat#: 529000

Name: Clofilium phosphate

CAS#: 68379-03-3 (Phosphate)

Chemical Formula: C21H37ClNO4P2-

Exact Mass: 433.2160

Molecular Weight: 433.95

Elemental Analysis: C, 58.12; H, 8.59; Cl, 8.17; N, 3.23; O, 14.75; P, 7.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
68379-02-2 (cation) 92953-10-1 (Tosylate) 68379-03-3 (Phosphate)
Synonym
Clofilium phosphate; LY 150378; LY150378; LY-150378
IUPAC/Chemical Name
N-(4-(4-chlorophenyl)butyl)-N,N-diethylheptan-1-aminium dihydrogen phosphate
InChi Key
HBLQZEWZVJXHKQ-UHFFFAOYSA-M
InChi Code
InChI=1S/C21H37ClN.H3O4P/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-5(2,3)4/h14-17H,4-13,18-19H2,1-3H3;(H3,1,2,3,4)/q+1;/p-1
SMILES Code
CCCCCCC[N+](CC)(CCCCC1=CC=C(Cl)C=C1)CC.OP(O)([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 433.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 29141209. 4: Shattock MJ, Park KC, Yang HY, Lee AWC, Niederer S, MacLeod KT, Winter J. Restitution slope is principally determined by steady-state action potential duration. Cardiovasc Res. 2017 Jun 1;113(7):817-828. doi: 10.1093/cvr/cvx063. PubMed PMID: 28371805; PubMed Central PMCID: PMC5437364. 5: Papp H, Sarusi A, Farkas AS, Takacs H, Kui P, Vincze D, Ivany E, Varro A, Papp JG, Forster T, Farkas A. Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits. J Physiol Pharmacol. 2016 Oct;67(5):731-737. PubMed PMID: 28011953. 6: Șterbuleac D, Maniu CL. An antiarrhythmic agent as a promising lead compound for targeting the hEAG1 ion channel in cancer therapy: insights from molecular dynamics simulations. Chem Biol Drug Des. 2016 Nov;88(5):683-689. doi: 10.1111/cbdd.12797. Epub 2016 Jul 11. PubMed PMID: 27254790. 7: Pitayu L, Baruffini E, Rodier C, Rötig A, Lodi T, Delahodde A. Combined use of Saccharomyces cerevisiae, Caenorhabditis elegans and patient fibroblasts leads to the identification of clofilium tosylate as a potential therapeutic chemical against POLG-related diseases. Hum Mol Genet. 2016 Feb 15;25(4):715-27. doi: 10.1093/hmg/ddv509. Epub 2015 Dec 21. PubMed PMID: 26692522. 8: Gualdani R, Tadini-Buoninsegni F, Roselli M, Defrenza I, Contino M, Colabufo NA, Lentini G. Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine. Pharmacol Res Perspect. 2015 Oct;3(5):e00160. doi: 10.1002/prp2.160. Epub 2015 Jul 31. PubMed PMID: 26516576; PubMed Central PMCID: PMC4618635. 9: Endo K, Kurokawa N, Kito H, Nakakura S, Fujii M, Ohya S. Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K(+) channel K(2P)5.1 in lymphoid cells and enhancement of its expression by splicing inhibition. Biochem Pharmacol. 2015 Dec 1;98(3):440-52. doi: 10.1016/j.bcp.2015.10.002. Epub 2015 Oct 20. PubMed PMID: 26475531. 10: Sánchez-Carranza O, Torres-Rodríguez P, Darszon A, Treviño CL, López-González I. Pharmacology of hSlo3 channels and their contribution in the capacitation-associated hyperpolarization of human sperm. Biochem Biophys Res Commun. 2015 Oct 23;466(3):554-9. doi: 10.1016/j.bbrc.2015.09.073. Epub 2015 Sep 14. PubMed PMID: 26381170. 11: Nicolas J, Hendriksen PJ, de Haan LH, Koning R, Rietjens IM, Bovee TF. In vitro detection of cardiotoxins or neurotoxins affecting ion channels or pumps using beating cardiomyocytes as alternative for animal testing. Toxicol In Vitro. 2015 Mar;29(2):281-8. doi: 10.1016/j.tiv.2014.11.010. Epub 2014 Dec 3. PubMed PMID: 25479353. 12: López-González I, Torres-Rodríguez P, Sánchez-Carranza O, Solís-López A, Santi CM, Darszon A, Treviño CL. Membrane hyperpolarization during human sperm capacitation. Mol Hum Reprod. 2014 Jul;20(7):619-29. doi: 10.1093/molehr/gau029. Epub 2014 Apr 15. PubMed PMID: 24737063; PubMed Central PMCID: PMC4072184. 13: Mansell SA, Publicover SJ, Barratt CL, Wilson SM. Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels. Mol Hum Reprod. 2014 May;20(5):392-408. doi: 10.1093/molehr/gau003. Epub 2014 Jan 16. PubMed PMID: 24442342; PubMed Central PMCID: PMC4004083. 14: Chung JW, Nam EC, Kim WT, Youm JB, Leem CH. Potassium currents in isolated deiters' cells of Guinea pig. Korean J Physiol Pharmacol. 2013 Dec;17(6):537-46. doi: 10.4196/kjpp.2013.17.6.537. Epub 2013 Dec 16. PubMed PMID: 24381504; PubMed Central PMCID: PMC3874442. 15: Girault A, Privé A, Trinh NT, Bardou O, Ferraro P, Joubert P, Bertrand R, Brochiero E. Identification of KvLQT1 K+ channels as new regulators of non-small cell lung cancer cell proliferation and migration. Int J Oncol. 2014 Mar;44(3):838-48. doi: 10.3892/ijo.2013.2228. Epub 2013 Dec 23. PubMed PMID: 24366043. 16: Louvel J, Carvalho JF, Yu Z, Soethoudt M, Lenselink EB, Klaasse E, Brussee J, Ijzerman AP. Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: a case of clofilium analogues. J Med Chem. 2013 Dec 12;56(23):9427-40. doi: 10.1021/jm4010434. Epub 2013 Nov 25. PubMed PMID: 24224763. 17: Han C, Pogwizd SM, Killingsworth CR, Zhou Z, He B. Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart. Heart Rhythm. 2013 Oct;10(10):1509-15. doi: 10.1016/j.hrthm.2013.06.010. Epub 2013 Jun 14. PubMed PMID: 23773986; PubMed Central PMCID: PMC3787973. 18: Khobragade SB, Gupta P, Gurav P, Chaudhari G, Gatne MM, Shingatgeri VM. Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models. J Pharmacol Pharmacother. 2013 Apr;4(2):116-24. doi: 10.4103/0976-500X.110892. PubMed PMID: 23759957; PubMed Central PMCID: PMC3669570. 19: Wahl V, Vogler S, Grosche A, Pannicke T, Ueffing M, Wiedemann P, Reichenbach A, Hauck SM, Bringmann A. Osteopontin inhibits osmotic swelling of retinal glial (Müller) cells by inducing release of VEGF. Neuroscience. 2013 Aug 29;246:59-72. doi: 10.1016/j.neuroscience.2013.04.045. Epub 2013 Apr 30. PubMed PMID: 23639879. 20: de Los Angeles Tejada M, Stolpe K, Meinild AK, Klaerke DA. Clofilium inhibits Slick and Slack potassium channels. Biologics. 2012;6:465-70. doi: 10.2147/BTT.S33827. Epub 2012 Dec 12. PubMed PMID: 23271893; PubMed Central PMCID: PMC3526865.