Synonym
Clofenapate; CCRIS388; CCRIS-388; CCRIS 388
IUPAC/Chemical Name
Propanoic acid, 2-((4'-chloro(1,1'-biphenyl)-4-yl)oxy)-2-methyl-, methyl ester
InChi Key
MNEIBEWKVRSDEX-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H22ClF4NO2.ClH/c23-19-8-5-16(14-18(19)22(25,26)27)21(30)9-12-28(13-10-21)11-1-2-20(29)15-3-6-17(24)7-4-15;/h3-8,14,30H,1-2,9-13H2;1H
SMILES Code
O=C(C1=CC=C(F)C=C1)CCCN2CCC(O)(C3=CC=C(Cl)C(C(F)(F)F)=C3)CC2.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
480.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Reddy JK, Lalwani ND, Reddy MK, Qureshi SA. Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidemic peroxisome proliferators. Cancer Res. 1982 Jan;42(1):259-66. PMID: 7053853.
2: Rao MS, Reddy MK, Reddy JK, Scarpelli DG. Response of chemically induced hepatocytelike cells in hamster pancreas to methyl clofenapate, a peroxisome proliferator. J Cell Biol. 1982 Oct;95(1):50-6. doi: 10.1083/jcb.95.1.50. PMID: 7142294; PMCID: PMC2112357.
3: Reddy JK. Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypolipidemic analog of CPIB. Am J Pathol. 1974 Apr;75(1):103-18. PMID: 4825610; PMCID: PMC1910808.
4: Verrando P, Négrel R, Grimaldi P, Murphy M, Ailhaud G. Differentiation of ob 17 preadipocytes to adipocytes. Triggering effects of clofenapate and indomethacin. Biochim Biophys Acta. 1981 Jan 26;663(1):255-65. doi: 10.1016/0005-2760(81)90212-5. PMID: 7011414.
5: Cruciani V, Rast C, Durand MJ, Nguyen-Ba G, Vasseur P. Comparative effects of clofibrate and methyl clofenapate on morphological transformation and intercellular communication of Syrian hamster embryo cells. Carcinogenesis. 1997 Apr;18(4):701-6. doi: 10.1093/carcin/18.4.701. PMID: 9111203.
6: Lefevre PA, Tinwell H, Galloway SM, Hill R, Mackay JM, Elcombe CR, Foster J, Randall V, Callander RD, Ashby J. Evaluation of the genetic toxicity of the peroxisome proliferator and carcinogen methyl clofenapate, including assays using Muta Mouse and Big Blue transgenic mice. Hum Exp Toxicol. 1994 Nov;13(11):764-75. doi: 10.1177/096032719401301105. PMID: 7857696.
7: Bowley M, Manning R, Brindlay DN. The tritium isotope effect of sn-glycerol 3-phosphate oxidase and the effects of clofenapate and N-(2-benzoyloxyethyl)norfenfluramine on the esterification of glycerol phosphate and dihydroxyacetone phosphate by rat liver mitochondria. Biochem J. 1973 Oct;136(2):421-7. doi: 10.1042/bj1360421. PMID: 4149445; PMCID: PMC1165969.
8: Krishnakantha TP, Kurup CK. Increase in hepatic catalase and glycerol phosphate dehydrogenase activities on administration of clofibrate and clofenapate to the rat. Biochem J. 1972 Nov;130(1):167-75. doi: 10.1042/bj1300167. PMID: 4655418; PMCID: PMC1174312.
9: Massie HR, Baird MB. Catalase levels in Drosophila and the lack of induction by hypolipidemic compounds. A brief note. Mech Ageing Dev. 1976 Jan- Feb;5(1):39-43. doi: 10.1016/0047-6374(76)90006-3. PMID: 817092.
10: Reddy JK, Krishnakantha TP, Rao MS. Microbody (peroxisome) proliferation in mouse kidney induced by methyl clofenapate. Virchows Arch B Cell Pathol. 1975;17(4):295-306. doi: 10.1007/BF02912856. PMID: 806162.
