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MedKoo Cat#: 413096 | Name: Clocinizine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clocinizine is a first-generation antihistamine of the diphenylmethylpiperazine class. It is marketed in Spain in combination with phenylpropanolamine under the brand name Senioral.

Chemical Structure

Clocinizine
Clocinizine
CAS#298-55-5 (free base)

Theoretical Analysis

MedKoo Cat#: 413096

Name: Clocinizine

CAS#: 298-55-5 (free base)

Chemical Formula: C26H27ClN2

Exact Mass: 402.1863

Molecular Weight: 402.97

Elemental Analysis: C, 77.50; H, 6.75; Cl, 8.80; N, 6.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
298-55-5 (free base) 39245-23-3 (HCl)
Synonym
Clocinizine; R522; R-522; R 522
IUPAC/Chemical Name
1-((4-chlorophenyl)(phenyl)methyl)-4-cinnamylpiperazine
InChi Key
ZSQANMZWGKYDER-JXMROGBWSA-N
InChi Code
InChI=1S/C26H27ClN2/c27-25-15-13-24(14-16-25)26(23-11-5-2-6-12-23)29-20-18-28(19-21-29)17-7-10-22-8-3-1-4-9-22/h1-16,26H,17-21H2/b10-7+
SMILES Code
Clc1ccc(C(c2ccccc2)N3CCN(CC3)C/C=C/c4ccccc4)cc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nowacka-Krukowska H, Rakowska M, Neubart K, Kobylińska M. High-performance liquid chromatographic assay for cinnarizine in human plasma. Acta Pol Pharm. 2007 Sep-Oct;64(5):407-11. PMID: 18540159. 2: Białecka W, Kulik A, Kaniewska T. Determination of active substances in antiallergic and antiphlogistic multicomponent preparations by high performance liquid chromatography (HPLC). Acta Pol Pharm. 2002 Jan-Feb;59(1):9-14. PMID: 12026119.