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MedKoo Cat#: 575892 | Name: Glyburide sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glyburide sodium is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide that can potentially be used to decrease cerebral edema.

Chemical Structure

Glyburide sodium
Glyburide sodium
CAS#20271-40-3 (sodium)

Theoretical Analysis

MedKoo Cat#: 575892

Name: Glyburide sodium

CAS#: 20271-40-3 (sodium)

Chemical Formula: C23H27ClN3NaO5S

Exact Mass: 0.0000

Molecular Weight: 515.98

Elemental Analysis: C, 53.54; H, 5.27; Cl, 6.87; N, 8.14; Na, 4.46; O, 15.50; S, 6.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
10238-21-8 (free) 20271-40-3 (sodium)
Synonym
Glibenclamide sodium; Glyburide sodium
IUPAC/Chemical Name
sodium ((4-(2-(5-chloro-2-methoxybenzamido)ethyl)phenyl)sulfonyl)(cyclohexylcarbamoyl)amide
InChi Key
FEAZVKXLWFYRJK-UHFFFAOYSA-M
InChi Code
InChI=1S/C23H28ClN3O5S.Na/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18;/h7-12,15,18H,2-6,13-14H2,1H3,(H3,25,26,27,28,29);/q;+1/p-1
SMILES Code
COC1=CC=C(C=C1C(NCCC2=CC=C(S(=O)([N-]C(NC3CCCCC3)=O)=O)C=C2)=O)Cl.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 515.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bircsak KM, Gupta V, Yuen PY, Gorczyca L, Weinberger BI, Vetrano AM, Aleksunes LM. Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental BCRP Transporter. J Pharmacol Exp Ther. 2016 Feb 5. pii: jpet.115.230185. [Epub ahead of print] PubMed PMID: 26850786. 2: Sheth KN, Elm JJ, Beslow LA, Sze GK, Kimberly WT. Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design. Neurocrit Care. 2016 Feb;24(1):132-9. doi: 10.1007/s12028-015-0189-7. PubMed PMID: 26268138. 3: Harper LM, Glover AV, Biggio JR, Tita A. Predicting failure of glyburide therapy in gestational diabetes. J Perinatol. 2016 Jan 21. doi: 10.1038/jp.2015.216. [Epub ahead of print] PubMed PMID: 26796130. 4: Rezai S, Vielman M, Henderson CE. Glyburide vs Insulin and Adverse Pregnancy Outcomes. JAMA Pediatr. 2015 Oct;169(10):974-5. doi: 10.1001/jamapediatrics.2015.1808. PubMed PMID: 26437012. 5: Tuccori M, Wu JW, Yin H, Majdan A, Azoulay L. The Use of Glyburide Compared With Other Sulfonylureas and the Risk of Cancer in Patients With Type 2 Diabetes. Diabetes Care. 2015 Nov;38(11):2083-9. doi: 10.2337/dc15-1358. Epub 2015 Sep 4. PubMed PMID: 26341130.