MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 413094 | Name: Clobetasone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clobetasone is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the hypothalamic–pituitary–adrenal axis.

Chemical Structure

Clobetasone
Clobetasone
CAS#54063-32-0 (free base)

Theoretical Analysis

MedKoo Cat#: 413094

Name: Clobetasone

CAS#: 54063-32-0 (free base)

Chemical Formula: C22H26ClFO4

Exact Mass: 408.1504

Molecular Weight: 408.89

Elemental Analysis: C, 64.62; H, 6.41; Cl, 8.67; F, 4.65; O, 15.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
54063-32-0 (free base) 25122-57-0 (butyrate)
Synonym
Clobetasone (free base); Clobetasona; Clobetasonum
IUPAC/Chemical Name
21-Chlor-9-fluor-17-hydroxy-16beta-methyl-1,4-pregnadien-3,11,20-trion
InChi Key
XXIFVOHLGBURIG-OZCCCYNHSA-N
InChi Code
InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
SMILES Code
C[C@@]1(C2)[C@](C(CCl)=O)(O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Naldi L, Diphoorn J. Seborrhoeic dermatitis of the scalp. BMJ Clin Evid. 2015 May 27;2015:1713. PMID: 26016669; PMCID: PMC4445675. 2: Goustas P, Cork MJ, Higson D. Eumovate (clobetasone butyrate 0.05%) cream: a review of clinical efficacy and safety. J Dermatolog Treat. 2003 Jun;14(2):71-85. doi: 10.1080/09546630310004180. PMID: 12775314. 3: Yamamoto Y, Fukami T, Koide T, Onuki Y, Suzuki T, Metori K, Katori N, Hiyama Y, Tomono K. Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments. Int J Pharm. 2014 Mar 10;463(1):62-7. doi: 10.1016/j.ijpharm.2013.12.054. Epub 2014 Jan 7. PMID: 24406671. 4: Williamson J, Eilon LA, Walker SR. Clobetasone butyrate eye drops. Effect on ocular inflammation and intraocular pressure. Trans Ophthalmol Soc U K. 1981;101(1):27-9. PMID: 6764318. 5: Lassus A. Clobetasone butyrate and hydrocortisone butyrate in the treatment of eczema: a double-blind comparison. Curr Med Res Opin. 1979;6(3):165-7. doi: 10.1185/03007997909109415. PMID: 391489. 6: Munro DD, Wilson L. Clobetasone butyrate, a new topical corticosteroid: clinical activity and effects on pituitary-adrenal axis function and model of epidermal atrophy. Br Med J. 1975 Sep 13;3(5984):626-8. doi: 10.1136/bmj.3.5984.626. PMID: 1164639; PMCID: PMC1674413. 7: Tsai S, Kageyama N, Warthan M, Cockerell CJ. Acrokeratoelastoidosis. Int J Dermatol. 2005 May;44(5):406-7. doi: 10.1111/j.1365-4632.2005.01980.x. PMID: 15869538. 8: Morley N, Fry L, Walker S. Clinical evaluation of clobetasone butyrate in the treatment of children with atopic eczema, and its effect on plasma corticosteroid levels. Curr Med Res Opin. 1976;4(3):223-8. doi: 10.1185/03007997609109308. PMID: 949903. 9: Eilon LA, Walker SR. Clinical evaluation of clobetasone butyrate eye drops in the treatment of anterior uveitis and its effects on intraocular pressure. Br J Ophthalmol. 1981 Sep;65(9):644-7. doi: 10.1136/bjo.65.9.644. PMID: 7028089; PMCID: PMC1039614. 10: Debnath SC, Richards AB. Concentration of clobetasone butyrate in aqueous humour. Br J Ophthalmol. 1983 Mar;67(3):203-5. doi: 10.1136/bjo.67.3.203. PMID: 6824626; PMCID: PMC1040009.